Guyonnet Sophie, Hooper Claudie, Bischoff-Ferrari Heike A, Parini Angelo, Santin Yohan, Pradère Jean-Philippe, Dray Cédric, Vellas Bruno
IHU HealthAge, Gérontopôle, Department of Geriatrics, CHU Toulouse, Toulouse, France.
CERPOP Inserm UMR 1295, University of Toulouse III, Toulouse, France.
Geroscience. 2025 Jun 16. doi: 10.1007/s11357-025-01718-2.
HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the lifespan-healthspan gap through novel translational bench-to-bedside research studies. HealthAge comprises the "INStitute for Prevention" "healthy aging" and "medicine Rejuvenative" (INSPIRE) human translational, outbred SWISS mice and African turquoise killifish (GRZ strain) cohorts in which aging is studied based on the concept of intrinsic capacity (IC). In this narrative review, we describe the three INSPIRE aging models (human cohort, n = 1109, age range 20 -102 years old with mean age ± standard deviation, 62.4 ± 19.0 years and 61.9% female; outbred SWISS mice, n = 1576 and African Turquoise killifish, n = 300) and explain how IC is assessed at the clinical (in humans) and biological level over time. HealthAge strives to elucidate the underlying biology of IC and to identify biomarkers of IC declines and novel gero-therapeutics using the clinical and biological data and biospecimens collected prospectively in the three species. The data sharing policy will foster scientific discovery through new multi-disciplinary collaborations. Thus, HealthAge will promote healthy aging using a unique translational platform based on IC phenotyping with the ultimate goal of preventing loss of human independence and alleviating health costs associated with an aging population.
“健康衰老年龄（HealthAge）”是由法国图卢兹的多个研究小组共同设计的，其共同目标是通过新颖的从实验室到临床的转化研究来缩小寿命与健康寿命之间的差距。“健康衰老年龄”项目包括“预防研究所”“健康老龄化”和“恢复活力医学”（INSPIRE）人体转化研究、远交系瑞士小鼠以及非洲青鳉（GRZ品系）队列研究，在这些研究中，基于内在能力（IC）的概念对衰老进行研究。在这篇叙述性综述中，我们描述了三种INSPIRE衰老模型（人体队列，n = 1109，年龄范围20 - 102岁，平均年龄±标准差为62.4±19.0岁，女性占61.9%；远交系瑞士小鼠，n = 1576；非洲青鳉，n = 300），并解释了如何随着时间的推移在临床（人类）和生物学水平上评估内在能力。“健康衰老年龄”项目致力于通过使用在这三个物种中前瞻性收集的临床和生物学数据以及生物样本，阐明内在能力的潜在生物学机制，识别内在能力下降的生物标志物以及新型老年治疗方法。数据共享政策将通过新的多学科合作促进科学发现。因此，“健康衰老年龄”项目将使用基于内在能力表型分析的独特转化平台来促进健康衰老，最终目标是防止人类失去独立性，并减轻与老龄化人口相关的医疗成本。
