Machaiah Ponnanna, Bajwa Supreet, Rudraraju Ravi Teja, Aneja Kunal, Tandiya Nitesh, Kapadia Shakir, Parmar Narendra, Singh Ashish, Chaudhari Yogesh, Hasan Rashid, Arora Vinod, Mehrotra Shubh, Patil Shailendra, Thakkar Ashok Kumar, Chandra Udita
Orthopaedics, Ramaiah Medical College and Hospital, Bangalore, IND.
Orthopaedics, Wockhardt Hospital, Mumbai Central, Mumbai, IND.
Cureus. 2025 May 14;17(5):e84104. doi: 10.7759/cureus.84104. eCollection 2025 May.
Background Hip fractures, particularly among the aging population, present a significant burden due to their association with morbidity, mortality, and long-term disability. Total hip arthroplasty (THA) is increasingly being adopted for fracture management in active patients, but implant performance data in real-world Indian settings remain sparse. This study assesses the early clinical efficacy, functional outcomes, and implant survivorship of the Latitud™ total hip replacement system (HRS) (Meril Healthcare Pvt. Ltd., Vapi, India), a novel prosthesis designed and manufactured in India, in patients undergoing THA for hip fractures. Methods This post hoc analysis derives from a prospective, multi-center, post-marketing surveillance study conducted across 11 tertiary care centers in India. A total of 44 adult patients presenting with various fracture patterns, including femoral neck, femoral head, intertrochanteric, sub-capital, and head-neck fractures, were evaluated following THA using the Latitud™ HRS. The primary objectives of the study were implant survivorship and adverse events over a two-year follow-up period, whereas the secondary objective of the study was to assess functional outcomes using the Harris hip score (HHS) and Oxford hip score (OHS) at six weeks, six months, one year, and two years postoperatively. Paired t-tests or Wilcoxon signed-rank tests were used for statistical comparisons, with p < 0.05 considered significant. Results A total of 44 patients were identified with the following fracture types: femoral neck (n = 18), femoral head (n = 8), head-neck (n = 2), and hip fractures (n = 12), with one case each of intertrochanteric, subcapital, intracapsular neck of femur (ICNF), and neck of femur fractures due to fall at home. Functional outcomes significantly improved, with the mean HHS increasing from 9.19 ± 9.52 preoperatively to 89.61 ± 3.57 (p < 0.0001), and the OHS from 4.89 ± 4.41 to 44.89 ± 3.77 (p < 0.0001). No serious adverse events were observed apart from the isolated revision case. At two years, implant survivorship was 97.7%, with a single revision due to polyethylene liner fracture. No other major complications, including infections, dislocations, or periprosthetic fractures, were reported. Conclusion The Latitud™ HRS demonstrated excellent short-term survivorship and marked functional improvement in patients with hip fractures, with minimal complications. These findings support its safety and effectiveness in the Indian clinical context and suggest its potential as a reliable implant for fracture-related THA. Further large-scale, long-term comparative studies are warranted to confirm these outcomes.
髋部骨折，尤其是在老年人群中，因其与发病率、死亡率和长期残疾相关，带来了重大负担。全髋关节置换术（THA）越来越多地被用于活跃患者的骨折治疗，但在印度实际临床环境中的植入物性能数据仍然稀少。本研究评估了Latitud™全髋关节置换系统（HRS）（印度瓦皮市梅里尔医疗保健私人有限公司）在接受THA治疗髋部骨折患者中的早期临床疗效、功能结果和植入物生存率，该系统是一款在印度设计和制造的新型假体。
本事后分析源自一项在印度11个三级医疗中心进行的前瞻性、多中心、上市后监测研究。共有44例成年患者，呈现各种骨折类型，包括股骨颈、股骨头、转子间、头下型和头颈骨折，在使用Latitud™ HRS进行THA后接受评估。该研究的主要目标是在两年随访期内的植入物生存率和不良事件，而次要目标是在术后六周、六个月、一年和两年使用Harris髋关节评分（HHS）和牛津髋关节评分（OHS）评估功能结果。采用配对t检验或Wilcoxon符号秩检验进行统计比较，p < 0.05被认为具有统计学意义。
共确定44例患者有以下骨折类型：股骨颈（n = 18）、股骨头（n = 8）、头颈（n = 2）和髋部骨折（n = 12），转子间、头下型、股骨囊内颈（ICNF）和在家摔倒导致的股骨颈骨折各1例。功能结果显著改善，平均HHS从术前的9.19 ± 9.52提高到89.61 ± 3.57（p < 0.0001），OHS从4.89 ± 4.41提高到44.89 ± 3.77（p < 0.0001）。除了单独的翻修病例外，未观察到严重不良事件。在两年时，植入物生存率为97.7%，因聚乙烯衬垫骨折进行了一次翻修。未报告其他主要并发症，包括感染、脱位或假体周围骨折。
Latitud™ HRS在髋部骨折患者中显示出优异的短期生存率和显著的功能改善，并发症极少。这些发现支持了其在印度临床环境中的安全性和有效性，并表明其作为骨折相关THA可靠植入物的潜力。需要进一步进行大规模、长期的比较研究来证实这些结果。
