Yang Wenwen, Cao Yanting, Li Jiayan, Zhang Xin, Liu Xiaoyi, Tian Ye, Shan Liang, Yang Yang
Department of Internal Medicine, Shaanxi Provincial People's Hospital, 256 Youyi West Road, Xi'an 710068, Shaanxi, China.
Xi'an Key Laboratory of Innovative Drug Research for Heart Failure, Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi'an 710069, China.
Int J Biol Sci. 2025 May 15;21(8):3478-3504. doi: 10.7150/ijbs.111288. eCollection 2025.
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Myocardial injury is a common complication in sepsis patients, which accelerates the progression of sepsis, leading to multiple organ dysfunction and poor prognosis. However, there are still many uncertainties about the characteristics, pathogenesis, treatment, and prognosis of sepsis-induced myocardial injury. While modern medical approaches dominate current clinical management of sepsis-induced myocardial injury, emerging evidence highlights the growing therapeutic potential of traditional Chinese medicine in this field, driven by advances in biomedical research. The integration of these two paradigms holds promise for elucidating the pathophysiological mechanisms and identifying novel therapeutic targets for sepsis-induced myocardial injury, which may accelerate the development of innovative treatment strategies. Therefore, this review comprehensively summarizes the pathogenesis and therapeutic interventions of sepsis-induced myocardial injury from both modern medicine and traditional Chinese medicine perspectives, and critically analyzes the two aiming to provide a valuable reference for researchers' understanding of sepsis-induced myocardial injury.
脓毒症是由宿主对感染的反应失调引起的危及生命的器官功能障碍。心肌损伤是脓毒症患者常见的并发症，它加速了脓毒症的进展，导致多器官功能障碍和预后不良。然而，关于脓毒症诱导的心肌损伤的特征、发病机制、治疗和预后仍存在许多不确定性。虽然现代医学方法在目前脓毒症诱导的心肌损伤的临床管理中占主导地位，但新出现的证据凸显了在生物医学研究进展的推动下，传统中医在该领域日益增长的治疗潜力。这两种范式的整合有望阐明脓毒症诱导的心肌损伤的病理生理机制并确定新的治疗靶点，这可能加速创新治疗策略的发展。因此，本综述从现代医学和传统中医的角度全面总结了脓毒症诱导的心肌损伤的发病机制和治疗干预措施，并对两者进行了批判性分析，旨在为研究人员理解脓毒症诱导的心肌损伤提供有价值的参考。
