Department of Cardiology, Central Hospital of Dalian University of Technology, 116033 Dalian, Liaoning, China.
Faculty of Medicine, Dalian University of Technology, 116024 Dalian, Liaoning, China.
Front Biosci (Landmark Ed). 2024 Feb 4;29(2):54. doi: 10.31083/j.fbl2902054.
Sepsis is defined as "a life-threatening organ dysfunction caused by a dysregulated host response to infection". Although the treatment of sepsis has evolved rapidly in the last few years, the morbidity and mortality of sepsis in clinical treatment are still climbing. Sirtuins (SIRTs) are a highly conserved family of histone deacetylation involved in energy metabolism. There are many mechanisms of sepsis-induced myocardial damage, and more and more evidence show that SIRTs play a vital role in the occurrence and development of sepsis-induced myocardial damage, including the regulation of sepsis inflammation, oxidative stress and metabolic signals. This review describes our understanding of the molecular mechanisms and pathophysiology of sepsis-induced myocardial damage, with a focus on disrupted SIRTs regulation. In addition, this review also describes the research status of related therapeutic drugs, so as to provide reference for the treatment of sepsis.
脓毒症被定义为“宿主对感染的失调反应引起的危及生命的器官功能障碍”。尽管近年来脓毒症的治疗有了迅速的发展，但在临床治疗中脓毒症的发病率和死亡率仍在攀升。沉默调节蛋白（SIRTs）是一个高度保守的组蛋白去乙酰化酶家族，参与能量代谢。脓毒症引起心肌损伤的机制有很多，越来越多的证据表明 SIRTs 在脓毒症引起心肌损伤的发生和发展中起着至关重要的作用，包括调节脓毒症炎症、氧化应激和代谢信号。本综述描述了我们对脓毒症引起心肌损伤的分子机制和病理生理学的理解，重点介绍了失调的 SIRTs 调节。此外，本综述还描述了相关治疗药物的研究现状，以期为脓毒症的治疗提供参考。
