Dale Madison, Studebaker-DeMartino Claudia, Morabito Rocco, Graffeo Vincent
West Virginia School of Osteopathic Medicine, 400 N Lee St, Lewisburg, WV, 24901, United States.
Saint Mary's Medical Center, 2900 1st Ave, Huntington, WV, 25702, United States.
Urol Case Rep. 2025 May 27;61:103084. doi: 10.1016/j.eucr.2025.103084. eCollection 2025 Jul.
Plasmacytoid urothelial carcinoma (PUC) is an aggressive variant of urothelial cell carcinoma (UCC) that has a tendency for unique presentation at time of diagnosis. We present a 68-year-old male who developed generalized abdominal pain with an incidental finding of acute renal failure secondary to ureteral strictures. He was subsequently diagnosed with PUC. Management of PUC is multifactorial with neoadjuvant chemotherapy followed by radical cystectomy. Despite these invasive treatments, the prognosis is often significantly inferior to typical UCC. This case demonstrates the need for high clinical suspicion in the setting of unpredicted strictures within the abdomen and pelvis.
浆细胞样尿路上皮癌（PUC）是尿路上皮细胞癌（UCC）的一种侵袭性变体，在诊断时往往有独特的表现。我们报告一名68岁男性，他出现了全身性腹痛，偶然发现继发于输尿管狭窄的急性肾衰竭。随后他被诊断为PUC。PUC的治疗是多方面的，先进行新辅助化疗，然后行根治性膀胱切除术。尽管有这些侵入性治疗，但预后通常明显差于典型的UCC。该病例表明，在腹部和骨盆出现意外狭窄的情况下，需要高度的临床怀疑。
