Teng Teng, Song Chunhong
Shandong Key Laboratory of Traditional Chinese Medicine and Stress Injury, Department of Laboratory Animal Center, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Front Pharmacol. 2025 May 30;16:1621510. doi: 10.3389/fphar.2025.1621510. eCollection 2025.
Anxiety and depression represent two of the most prevalent mental disorders worldwide, with current pharmacotherapies often limited by adverse effects and treatment resistance. Consequently, research into natural products for mental health interventions has attracted growing scientific interest. Quercetin, a bioactive flavonoid ubiquitously present in plant-derived flowers, fruits, and dietary sources, exhibits diverse pharmacological properties, including antioxidant, anxiolytic, and antidepressant activities. This review systematically summarizes the fundamental characteristics of quercetin, focusing on its core molecular mechanisms in alleviating anxiety- and depression-like behaviors, preclinical evidence from experimental models, and the current landscape of clinical investigations. By critically analyzing its therapeutic advantages, translational challenges, and emerging research priorities, this synthesis aims to offer a theoretical foundation for the development of quercetin-based formulations and their clinical implementation in mood disorder management.
焦虑和抑郁是全球最普遍的两种精神障碍，目前的药物治疗常常受到副作用和治疗抵抗的限制。因此，对用于心理健康干预的天然产物的研究引起了越来越多的科学兴趣。槲皮素是一种广泛存在于植物来源的花朵、果实和膳食中的生物活性黄酮类化合物，具有多种药理特性，包括抗氧化、抗焦虑和抗抑郁活性。本综述系统总结了槲皮素的基本特征，重点关注其缓解焦虑样和抑郁样行为的核心分子机制、实验模型的临床前证据以及当前的临床研究概况。通过批判性地分析其治疗优势、转化挑战和新出现的研究重点，本综述旨在为基于槲皮素的制剂开发及其在情绪障碍管理中的临床应用提供理论基础。
