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1
Differences in fragmentation between bound and unbound bovine secretory component suggest a model for its interaction with polymeric immunoglobulin.结合态与游离态牛分泌成分在片段化上的差异提示了其与聚合免疫球蛋白相互作用的一种模型。
Biochem J. 1985 Aug 1;229(3):759-63. doi: 10.1042/bj2290759.
2
Tryptic digestion of bovine secretory IgA at elevated temperature and in urea. Isolation of SC domain 1 which is covalently bound to IgA dimer and binds non-covalently to IgM.在高温和尿素条件下对牛分泌型IgA进行胰蛋白酶消化。分离与IgA二聚体共价结合并与IgM非共价结合的SC结构域1。
Int J Biochem. 1989;21(5):549-54. doi: 10.1016/0020-711x(89)90136-5.
3
Fragmentation and reduction of bovine secretory component. Preparation of a biologically active fragment and some evidence for a multiple-domain structure.牛分泌成分的片段化与降解。一种生物活性片段的制备及多结构域结构的一些证据。
Biochem J. 1985 Mar 15;226(3):661-7. doi: 10.1042/bj2260661.
4
The sites of tryptic cleavage in bovine secretory component: structural and functional implications.牛分泌成分中胰蛋白酶裂解位点：结构与功能意义
Biochim Biophys Acta. 1987 Apr 30;912(3):365-70. doi: 10.1016/0167-4838(87)90041-0.
5
Secretory component (SC): preferential binding to heavy (greater than 11S) IgA polymers and IgM in serum, in contrast to predominance of 11S and free SC forms in secretions.分泌成分（SC）：与血清中重链（大于11S）IgA聚合物和IgM优先结合，而在分泌物中则以11S和游离SC形式为主。
Clin Exp Immunol. 1982 Sep;49(3):717-24.
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Cyanogen bromide cleavage of bovine secretory component and its tryptic fragments.溴化氰对牛分泌成分及其胰蛋白酶消化片段的裂解作用
Int J Biochem. 1988;20(8):873-9. doi: 10.1016/0020-711x(88)90077-8.
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The structure of bovine secretory component.牛分泌成分的结构。
Vet Immunol Immunopathol. 1987 Dec;17(1-4):37-49. doi: 10.1016/0165-2427(87)90125-5.
8
Significance of different J chain profiles in human tissues: generation of IgA and IgM with binding site for secretory component is related to the J chain expressing capacity of the total local immunocyte population, including IgG and IgD producing cells, and depends on the clinical state of the tissue.人组织中不同J链谱的意义：具有分泌成分结合位点的IgA和IgM的产生与包括产生IgG和IgD的细胞在内的局部免疫细胞总体的J链表达能力有关，并取决于组织的临床状态。
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Interaction of the fluorescence-labeled secretory component with human polymeric immunoglobulins.荧光标记的分泌成分与人聚合免疫球蛋白的相互作用。
Biochemistry. 1984 Dec 18;23(26):6736-44. doi: 10.1021/bi00321a070.
10
Purification of polymeric immunoglobulin from cell culture supernatants by affinity chromatography using secretory component.使用分泌成分通过亲和色谱法从细胞培养上清液中纯化聚合免疫球蛋白。
J Immunol Methods. 1987 Nov 23;104(1-2):237-43. doi: 10.1016/0022-1759(87)90510-2.

引用本文的文献

1
The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses.非平面的分泌型IgA2和近平面的分泌型IgA1溶液结构解释了它们不同的黏膜免疫反应。
J Biol Chem. 2009 Feb 20;284(8):5077-87. doi: 10.1074/jbc.M807529200. Epub 2008 Dec 23.
2
A bovine epithelial membrane protein that binds polymeric immunoglobulin and has a structure related to that of bovine secretory component.一种结合聚合免疫球蛋白且结构与牛分泌成分相关的牛上皮膜蛋白。
Biochem J. 1986 Jan 1;233(1):37-40. doi: 10.1042/bj2330037.

本文引用的文献

1
Physicochemical and immunochemical studies on bovine IgA and glycoprotein-a.牛IgA与糖蛋白-a的物理化学和免疫化学研究
Biochim Biophys Acta. 1971 Dec 28;251(3):435-49. doi: 10.1016/0005-2795(71)90133-4.
2
The membrane receptor for polymeric immunoglobulin is structurally related to secretory component. Isolation and characterization of membrane secretory component from rabbit liver and mammary gland.聚合免疫球蛋白的膜受体在结构上与分泌成分相关。兔肝脏和乳腺中膜分泌成分的分离与特性分析。
J Biol Chem. 1981 Dec 10;256(23):12490-5.
3
Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.人Fc片段及其与金黄色葡萄球菌蛋白A的B片段复合物在2.9埃和2.8埃分辨率下的晶体学精修与原子模型。
Biochemistry. 1981 Apr 28;20(9):2361-70.
4
A comparison of the proteolytic fragmentation of immunoglobulin M from several different mammalian species.几种不同哺乳动物物种免疫球蛋白M的蛋白水解片段化比较。
Comp Biochem Physiol B. 1982;71(3):475-82. doi: 10.1016/0305-0491(82)90411-4.
5
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains.IgA和IgM跨上皮运输的受体包含多个免疫球蛋白样结构域。
Nature. 1984;308(5954):37-43. doi: 10.1038/308037a0.
6
Characterization of epitopes of human secretory component on free secretory component, secretory IgA, and membrane-associated secretory component.游离分泌成分、分泌型IgA及膜相关分泌成分上人类分泌成分表位的特性分析
J Immunol. 1984 Oct;133(4):2116-25.
7
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
8
Studies on the structural and conformational basis for the relative resistance of serum and secretory immunoglobulin A to proteolysis.关于血清和分泌型免疫球蛋白A对蛋白水解相对抗性的结构和构象基础的研究。
J Immunol. 1974 Mar;112(3):949-59.
9
Structure of a lambda-type Bence-Jones protein at 3.5-A resolution.分辨率为3.5埃的λ型本斯-琼斯蛋白的结构
Biochemistry. 1973 Nov 6;12(23):4620-31. doi: 10.1021/bi00747a013.
10
Mucosal and glandular distribution of immunoglobulin components: differential localization of free and bound SC in secretory epithelial cells.免疫球蛋白成分的黏膜和腺体分布：分泌上皮细胞中游离和结合分泌成分的差异定位。
J Immunol. 1974 Apr;112(4):1553-9.

结合态与游离态牛分泌成分在片段化上的差异提示了其与聚合免疫球蛋白相互作用的一种模型。

Differences in fragmentation between bound and unbound bovine secretory component suggest a model for its interaction with polymeric immunoglobulin.

作者信息

Beale D

出版信息

Biochem J. 1985 Aug 1;229(3):759-63. doi: 10.1042/bj2290759.

DOI:10.1042/bj2290759
PMID:4052023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1145121/
Abstract

Unbound bovine secretory component was cleaved into two-domain and one-domain fragments by trypsin within 1 h. Bovine secretory component covalently bound to bovine IgA dimer, as in secretory IgA, was much more resistant to fragmentation, which did not proceed beyond the three-domain stage even after 5 h. Bovine secretory component non-covalently bound to bovine IgM or to human IgM or IgA polymer was also relatively resistant to fragmentation, which again was largely arrested at the three-domain stage. A model for the binding of secretory component to polymeric immunoglobulin is proposed.

摘要

未结合的牛分泌成分在1小时内被胰蛋白酶切割成两个结构域和一个结构域的片段。与分泌型IgA一样，与牛IgA二聚体共价结合的牛分泌成分对片段化的抵抗力要强得多，即使在5小时后，片段化也不会超过三个结构域阶段。与牛IgM或人IgM或IgA聚合物非共价结合的牛分泌成分对片段化也具有相对抗性，同样在很大程度上在三个结构域阶段停止。提出了分泌成分与聚合免疫球蛋白结合的模型。