Ptomey Lauren T, Helsel Brian C, Washburn Richard A, Montgomery Robert N, Krebill Ron, Danon Jessica C, Sherman Joseph R, Forsha Daniel, Bodde Amy, Szabo-Reed Amanda N, Gorczyca Anna M, Donnelly Joseph E
Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USA.
Department of Neurology University of Kansas Medical Center Kansas City Kansas USA.
Alzheimers Dement (N Y). 2025 Jun 12;11(2):e70115. doi: 10.1002/trc2.70115. eCollection 2025 Apr-Jun.
Alzheimer's disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Participation in moderate-to-vigorous physical activity (MVPA) may prevent or delay the onset of AD. Therefore, we evaluated the potential effectiveness of a remotely delivered home-based group exercise (≈8/group) to increase daily MVPA and cardiorespiratory fitness in adults with DS to a level that may be associated with delaying AD in adults with DS.
Adults with DS ( = 81, age ≈27 years 55% female) without dementia were randomized (2:2:1) to a 12-month intervention, which included 40-min exercise sessions scheduled once (remote low (RL), = 32) or 3 times per week (remote high (RH), = 34) plus twice monthly 20-min individual remotely delivered support/education sessions or to a control arm who attended twice monthly support/education sessions only (SE, = 15). MVPA (minutes/day) was assessed by accelerometer, and cardiorespiratory fitness (VO mL/kg/min) was assessed using a maximal treadmill test.
Participant retention at 12 months was 100%. Attendance at exercise and support/education sessions averaged ~85% and ~86%, respectively. Linear mixed modeling revealed no significant differences in change in MVPA from baseline to 12 months between the RH (10 min/day) and the RL arms (2 min/day, = 0.06) or the RH and SE arms (1 min/day = 0.13). The change in VO₂ differed significantly between the RH (2.0 ± 4.6 mL/kg/min) and RL arms (-1.1 ± 3.0 mL/kg/min, = 0.04) but not between the RH and SE arms (1.2 ± 5.3 mL/kg/min, = 0.85).
Our results suggest that remotely delivered group exercise (3 times/week) in conjunction with twice-monthly support/education is feasible and may increase daily MVPA and cardiorespiratory fitness to a level that may be associated with improvements in health and cognitive parameters in adults with DS.
This trial was approved by the Institutional Review Board at the University of Kansas Medical Center and was registered on clinicaltrials.gov (NCT04048759).
Evidence suggests that exercise may delay Alzheimer's disease (AD) in the general population, but its impact on adults with Down syndrome (DS) remains unknown.Adults attended remote exercise sessions either 1 or 3 times a week or received basic education about exercise.Those who attend exercise sessions 3 times a week increased their physical activity by 70 min per week.Those who attend exercise sessions 3 times a week improve their cardiorespiratory fitness.Remote exercise can be used in future AD prevention trials in adults with DS.
阿尔茨海默病（AD）是唐氏综合征（DS）患者的主要死因。参与中度至剧烈体育活动（MVPA）可能预防或延缓AD的发病。因此，我们评估了一种通过远程方式开展的居家小组运动（每组约8人）在提高DS成年患者每日MVPA及心肺适能方面的潜在效果，使其达到可能与延缓DS成年患者AD发病相关的水平。
将81名无痴呆的DS成年患者（年龄约27岁，55%为女性）随机分为三组（2:2:1），进行为期12个月的干预。干预组包括每周一次40分钟的锻炼课程（远程低强度组（RL），n = 32）或每周三次40分钟的锻炼课程（远程高强度组（RH），n = 34），外加每月两次20分钟的个人远程支持/教育课程；对照组仅参加每月两次的支持/教育课程（SE，n = 15）。通过加速度计评估MVPA（分钟/天），使用最大跑步机测试评估心肺适能（VO₂ mL/kg/min）。
12个月时参与者保留率为100%。锻炼课程和支持/教育课程的出勤率平均分别约为85%和86%。线性混合模型显示，RH组（每天10分钟）与RL组（每天2分钟，P = 0.06）或RH组与SE组（每天1分钟，P = 0.13）从基线到12个月的MVPA变化无显著差异。RH组（2.0 ± 4.6 mL/kg/min）与RL组（-1.1 ± 3.0 mL/kg/min，P = 0.04）的VO₂变化有显著差异，但RH组与SE组（1.2 ± 5.3 mL/kg/min，P = 0.85）无显著差异。
我们的结果表明，每周三次远程小组运动结合每月两次支持/教育是可行的，可能会将每日MVPA和心肺适能提高到与改善DS成年患者健康和认知参数相关的水平。
本试验经堪萨斯大学医学中心机构审查委员会批准，并在clinicaltrials.gov上注册（NCT04048759）。
有证据表明运动可能延缓普通人群中的阿尔茨海默病（AD），但其对唐氏综合征（DS）成年患者的影响尚不清楚。成年患者每周参加1次或3次远程锻炼课程或接受关于运动 的基础教育。每周参加3次锻炼课程的患者每周身体活动增加70分钟。每周参加3次锻炼课程的患者心肺适能得到改善。远程锻炼可用于未来DS成年患者的AD预防试验。
Zotero 插件
