阿尔茨海默病高危人群的心肺适能与认知
Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease.
作者信息
Vesperman Clayton J, Wang Rui, Schultz Stephanie A, Law Lena L, Dougherty Ryan J, Ma Yue, Oh Jennifer M, Edwards Dorothy F, Gallagher Catherine L, Chin Nathaniel A, Asthana Sanjay, Hermann Bruce P, Sager Mark A, Johnson Sterling C, Cook Dane B, Okonkwo Ozioma C
机构信息
Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
The Swedish School of Sport and Health Sciences GIH Stockholm Sweden.
出版信息
Alzheimers Dement (Amst). 2022 Jul 8;14(1):e12330. doi: 10.1002/dad2.12330. eCollection 2022.
INTRODUCTION
This study examined the relationship between cardiorespiratory fitness (CRF) and longitudinal cognitive functioning in a cohort enriched with risk factors for Alzheimer's disease (AD).
METHODS
A total of 155 enrollees in the Wisconsin Registry for Alzheimer's Prevention completed repeat comprehensive neuropsychological evaluations that assessed six cognitive domains. Peak oxygen consumption (VOpeak) was the primary measure of CRF. Random effects regression was used to investigate the effect of CRF on cognitive trajectories.
RESULTS
Higher CRF was associated with slower decline in the cognitive domains of verbal learning and memory ( < .01) and visual learning and memory ( < .042). Secondary analyses indicated that these effects were stronger among men than women, and for noncarriers of the apolipoprotein E ε4 allele.
DISCUSSION
Higher CRF was associated with a slower rate of the decline in episodic memory that occurs as a natural consequence of aging in a cohort enriched with risk factors for AD.
引言
本研究在一个富含阿尔茨海默病（AD）风险因素的队列中，考察了心肺适能（CRF）与纵向认知功能之间的关系。
方法
共有155名威斯康星州阿尔茨海默病预防登记处的参与者完成了重复的全面神经心理学评估，该评估对六个认知领域进行了评估。峰值耗氧量（VOpeak）是CRF的主要测量指标。随机效应回归用于研究CRF对认知轨迹的影响。
结果
较高的CRF与言语学习和记忆（<.01）以及视觉学习和记忆（<.042）认知领域的较慢衰退相关。二次分析表明，这些影响在男性中比在女性中更强，并且对于载脂蛋白Eε4等位基因的非携带者也是如此。
讨论
在一个富含AD风险因素的队列中，较高的CRF与随着衰老自然发生的情景记忆衰退速度较慢相关。
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