Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; School of Human Ecology, University of Wisconsin-Madison, Madison, WI, USA.
Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Neurobiol Aging. 2021 Nov;107:118-127. doi: 10.1016/j.neurobiolaging.2021.07.016. Epub 2021 Jul 29.
Adults with Down syndrome (DS) are at risk for Alzheimer's disease. Despite sharing trisomy 21, however, there is variability in the age of disease onset. This variability may mean that other factors, such as lifestyle, influence cognitive aging and disease timing. The present study assessed the association between everyday life physical activity using an actigraph accelerometer and cognitive functioning and early Alzheimer's disease pathology via positron emission tomography amyloid-β and tau and diffusion tension imaging measures of white matter integrity in 61 non-demented adults with DS. Percent time in sedentary behavior and in moderate-to-vigorous activity were associated (negatively and positively, respectively) with cognitive functioning (r = -.472 to .572, p < 0.05). Neither sedentary behavior nor moderate-to-vigorous activity were associated with amyloid-β or tau, but both were associated with white matter integrity in the superior and inferior longitudinal fasciculus (Fractional Anisotropy: r = -.397 to -.419, p < 0.05; Mean Diffusivity: r = .400, p < 0.05). Longitudinal studies are needed to determine if physical activity promotes healthy aging in DS.
患有唐氏综合征（DS）的成年人易患阿尔茨海默病。然而，尽管他们都存在 21 号染色体三体，但其发病年龄存在差异。这种差异可能意味着其他因素，如生活方式，会影响认知衰老和疾病发生的时间。本研究通过正电子发射断层扫描（PET）β淀粉样蛋白和 tau 以及弥散张量成像（DTI）测量白质完整性，评估了 61 名非痴呆唐氏综合征成年人日常生活体力活动（使用加速度计测量）与认知功能以及早期阿尔茨海默病病理之间的关系。久坐行为和中高强度体力活动的时间百分比分别与认知功能呈负相关（r=-.472 至.572，p<0.05）和正相关（r=-.472 至.572，p<0.05）。久坐行为和中高强度体力活动均与淀粉样蛋白-β或 tau 无相关性，但均与上、下纵束的白质完整性呈相关性（各向异性分数：r=-.397 至 -.419，p<0.05；平均弥散度：r=-.400，p<0.05）。需要进行纵向研究来确定体力活动是否能促进 DS 人群的健康衰老。
