Dodge W, Thomas M
Biochem Biophys Res Commun. 1985 Sep 16;131(2):731-5. doi: 10.1016/0006-291x(85)91299-9.
The clonal proliferation of chicken granulocytic progenitors was inhibited 5-20-fold by the eicosanoid, 5-HETE, at 1.0 microM. Inhibition occurred at the lowest concentration measured (0.12 microM). This compound at 0.6 to 1.0 microM also inhibited the clonal proliferation of chick embryo fibroblasts by as much as 10-fold.
类花生酸5-羟二十碳四烯酸(5-HETE)在浓度为1.0微摩尔时,可使鸡粒细胞祖细胞的克隆增殖受到5至20倍的抑制。在测得的最低浓度(0.12微摩尔)时就出现了抑制作用。该化合物在浓度为0.6至1.0微摩尔时,还可使鸡胚成纤维细胞的克隆增殖受到高达10倍的抑制。