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5-羟基二十碳四烯酸对雏鸡粒细胞祖细胞和胚胎成纤维细胞增殖的影响。

The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chick.

作者信息

Dodge W, Thomas M

出版信息

Biochem Biophys Res Commun. 1985 Sep 16;131(2):731-5. doi: 10.1016/0006-291x(85)91299-9.

DOI:10.1016/0006-291x(85)91299-9
PMID:4052072
Abstract

The clonal proliferation of chicken granulocytic progenitors was inhibited 5-20-fold by the eicosanoid, 5-HETE, at 1.0 microM. Inhibition occurred at the lowest concentration measured (0.12 microM). This compound at 0.6 to 1.0 microM also inhibited the clonal proliferation of chick embryo fibroblasts by as much as 10-fold.

摘要

类花生酸5-羟二十碳四烯酸(5-HETE)在浓度为1.0微摩尔时,可使鸡粒细胞祖细胞的克隆增殖受到5至20倍的抑制。在测得的最低浓度(0.12微摩尔)时就出现了抑制作用。该化合物在浓度为0.6至1.0微摩尔时,还可使鸡胚成纤维细胞的克隆增殖受到高达10倍的抑制。

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The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chick.5-羟基二十碳四烯酸对雏鸡粒细胞祖细胞和胚胎成纤维细胞增殖的影响。
Biochem Biophys Res Commun. 1985 Sep 16;131(2):731-5. doi: 10.1016/0006-291x(85)91299-9.
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