Hao Minyan, Wijaya Chandra Sugiarto, Lu Linyao, Wang Xian, Zhou Jia
Department of Medical Oncology, Cancer Center of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University Hangzhou 310016, Zhejiang, China.
Am J Cancer Res. 2025 May 25;15(5):2338-2352. doi: 10.62347/RIWH3000. eCollection 2025.
Paraspeckle Component 1 (PSPC1), a Drosophila behavior/human splicing (DBHS) protein family member, represents a pivotal component within paraspeckles. It exerts indispensable functions across a wide array of biological processes, encompassing gene expression, the DNA damage response, the regulation of circadian rhythms, spermatogenesis, cell fate determination, and cancer metastasis. Notably, PSPC1 exhibits overexpression in several types of cancer, including hepatocellular carcinoma, lung cancer, and breast cancer, where it actively contributes to tumorigenesis. This overexpression phenomenon implies that PSPC1 holds the potential to serve as both a biomarker and a therapeutic target for these malignancies. Consequently, a substantial amount of research has been conducted to explore its structure, functions, and role in cancer development and progression. This review article aims to comprehensively summarize the current findings regarding PSPC1.
副斑点成分1（PSPC1）是果蝇行为/人类剪接（DBHS）蛋白家族成员，是副斑点中的关键成分。它在广泛的生物过程中发挥着不可或缺的作用，包括基因表达、DNA损伤反应、昼夜节律调节、精子发生、细胞命运决定和癌症转移。值得注意的是，PSPC1在几种类型的癌症中均有过表达，包括肝细胞癌、肺癌和乳腺癌，它在这些癌症中积极促进肿瘤发生。这种过表达现象表明，PSPC1有潜力作为这些恶性肿瘤的生物标志物和治疗靶点。因此，人们已经开展了大量研究来探索其结构、功能以及在癌症发生和发展中的作用。这篇综述文章旨在全面总结目前关于PSPC1的研究结果。
