全球视角下过氧化物酶体增殖物激活受体 γ（PPARγ）在异位脂肪沉积中的作用：综述。
The global perspective on peroxisome proliferator-activated receptor γ (PPARγ) in ectopic fat deposition: A review.
机构信息
Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China; Key Laboratory of Livestock and Poultry Multi-omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Chongqing Academy of Animal Science, Rongchang, Chongqing 402460, China.
出版信息
Int J Biol Macromol. 2023 Dec 31;253(Pt 5):127042. doi: 10.1016/j.ijbiomac.2023.127042. Epub 2023 Sep 22.
Excessive expansion of adipocytes can have unhealthy consequences as excess free fatty acids enter other tissues and cause ectopic fat deposition by resynthesizing triglycerides. This lipid accumulation in various tissues is harmful and can increase the risk of related metabolic diseases such as type II diabetes, cardiovascular disease, and insulin resistance. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily that play a key role in energy metabolism as fatty acid metabolism sensors, and peroxisome proliferator-activated receptor γ (PPARγ) is the main subtype responsible for fat cell differentiation and adipogenesis. In this paper, we introduce the main structure and function of PPARγ and its regulatory role in the process of lipogenesis in the liver, kidney, skeletal muscle, and pancreas. This information can serve as a reference for further understanding the regulatory mechanisms and measures of the PPAR family in the process of ectopic fat deposition.
脂肪细胞过度扩张会产生不健康的后果，因为过量的游离脂肪酸进入其他组织，并通过重新合成甘油三酯导致异位脂肪沉积。这种在各种组织中的脂质积累是有害的，并可能增加相关代谢疾病的风险，如 2 型糖尿病、心血管疾病和胰岛素抵抗。过氧化物酶体增殖物激活受体 (PPAR) 是核激素受体超家族的成员，作为脂肪酸代谢传感器，在能量代谢中发挥关键作用，过氧化物酶体增殖物激活受体 γ (PPARγ) 是主要负责脂肪细胞分化和脂肪生成的亚型。本文介绍了 PPARγ 的主要结构和功能及其在肝脏、肾脏、骨骼肌和胰腺中脂生成过程中的调节作用。这些信息可以为进一步了解 PPAR 家族在异位脂肪沉积过程中的调节机制和措施提供参考。
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