Feng Dandan, Wang Jianchun
Department of Geriatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Front Cardiovasc Med. 2025 May 30;12:1498826. doi: 10.3389/fcvm.2025.1498826. eCollection 2025.
The incidence and mortality of thrombotic diseases in the aged population are increasing year by year, which seriously affect the quality of life of the elderly. At present, antithrombotic drugs used in clinical practice have good efficacy, but they caused different degrees of age-dependent bleeding risk. Therefore, there is an urgent need to develop effective antithrombotic drugs with less risk of bleeding. Recent studies have shown that factor Ⅺ inhibitors can effectively reduce the incidence of thromboembolic events without increasing the risk of bleeding. Therefore, factor Ⅺ inhibitors are expected to be safe and effective new anticoagulants, providing a new sight for the prevention and treatment of thrombotic diseases. This paper reviews the biological functions of factor Ⅺ, the types and characteristics of factor Ⅺ inhibitors and the related research progress of factor Ⅺ inhibitors.
老年人群中血栓性疾病的发病率和死亡率逐年上升，严重影响老年人的生活质量。目前，临床实践中使用的抗血栓药物疗效良好，但会引发不同程度的年龄依赖性出血风险。因此，迫切需要开发出血风险较低的有效抗血栓药物。最近的研究表明，因子Ⅺ抑制剂可有效降低血栓栓塞事件的发生率，且不增加出血风险。因此，因子Ⅺ抑制剂有望成为安全有效的新型抗凝剂，为血栓性疾病的防治提供新视角。本文综述了因子Ⅺ的生物学功能、因子Ⅺ抑制剂的类型和特点以及因子Ⅺ抑制剂的相关研究进展。
