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circFOXO3 facilitated endothelial cell senescence and atherosclerosis through binding to HnRNPK.

作者信息

Wu Jing-Yu, Zhou Yu-Lan, Lu Shui-Hong, Yang Zhi-Peng, Liao Zhao-Fu, Liu Dong-Liang, Mo Hai-Liang, Xie Yi-Tuan, Liu Xinguang, Xiong Xing-Dong

机构信息

Dongguan Key Laboratory of Aging and Anti-Aging, Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong 523808, China.

School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong 523808, China.

出版信息

Genes Dis. 2025 Jan 4;12(5):101517. doi: 10.1016/j.gendis.2025.101517. eCollection 2025 Sep.

DOI:10.1016/j.gendis.2025.101517
PMID:40520995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12166678/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b38/12166678/f28159f4e2f2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b38/12166678/f28159f4e2f2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b38/12166678/f28159f4e2f2/gr1.jpg

相似文献

1
circFOXO3 facilitated endothelial cell senescence and atherosclerosis through binding to HnRNPK.环状FOXO3通过与异质性核糖核蛋白K（HnRNPK）结合促进内皮细胞衰老和动脉粥样硬化。
Genes Dis. 2025 Jan 4;12(5):101517. doi: 10.1016/j.gendis.2025.101517. eCollection 2025 Sep.
2
Loss of HNRNPK During Cell Senescence Linked to Reduced Production of CDC20.细胞衰老过程中HNRNPK的缺失与CDC20产生减少有关。
Mol Cell Biol. 2025;45(3):129-141. doi: 10.1080/10985549.2024.2443590. Epub 2025 Jan 13.
3
Circular RNA circFoxo3 Promotes Granulosa Cell Apoptosis Under Oxidative Stress Through Regulation of FOXO3 Protein.环状 RNA circFoxo3 通过调控 FOXO3 蛋白促进氧化应激下的颗粒细胞凋亡。
DNA Cell Biol. 2022 Dec;41(12):1026-1037. doi: 10.1089/dna.2022.0449. Epub 2022 Nov 17.
4
CircFOXO3 functions as a molecular sponge for miR-143-3p to promote the progression of gastric carcinoma via upregulating USP44.CircFOXO3 作为 miR-143-3p 的分子海绵通过上调 USP44 促进胃癌的进展。
Gene. 2020 Aug 30;753:144798. doi: 10.1016/j.gene.2020.144798. Epub 2020 May 20.
5
Pathogenic mechanisms and the potential clinical value of circFoxo3 in cancers.环状 Foxo3 在癌症中的致病机制及潜在临床价值
Mol Ther Nucleic Acids. 2021 Jan 20;23:908-917. doi: 10.1016/j.omtn.2021.01.010. eCollection 2021 Mar 5.
6
CircFoxo3 Promotes Adriamycin Resistance Through Regulation of miR-199a-5p/ATP Binding Cassette Subfamily C Member 1 Axis in Hepatocellular Carcinoma.环状RNA Foxo3通过调控miR-199a-5p/ATP结合盒转运体C亚家族成员1轴促进肝癌阿霉素耐药
Onco Targets Ther. 2020 Jun 8;13:5113-5122. doi: 10.2147/OTT.S243571. eCollection 2020.
7
CircFOXO3 mediates hypoxia-induced autophagy of endometrial stromal cells in endometriosis.环状结构 FOXO3 介导子宫内膜异位症中缺氧诱导的子宫内膜基质细胞自噬。
FASEB J. 2024 Mar 15;38(5):e23515. doi: 10.1096/fj.202301654RR.
8
Circular RNA circFOXO3 regulates KDM2A by targeting miR-214 to promote tumor growth and metastasis in oral squamous cell carcinoma.环状 RNA circFOXO3 通过靶向 miR-214 调控 KDM2A 促进口腔鳞状细胞癌的肿瘤生长和转移。
J Cell Mol Med. 2022 Mar;26(6):1842-1852. doi: 10.1111/jcmm.16533. Epub 2021 Jun 12.
9
Circular RNA circFOXO3 facilitate non-small cell lung cancer progression through upregulating HMGB3 via sponging miR-545-3p/miR-506-3p.环状 RNA circFOXO3 通过海绵吸附 miR-545-3p/miR-506-3p 而上调 HMGB3 促进非小细胞肺癌进展。
Tissue Cell. 2022 Apr;75:101702. doi: 10.1016/j.tice.2021.101702. Epub 2021 Nov 25.
10
Effects of circFOXO3 on the Proliferation and Invasion of Liver Cancer Cells by Regulating PI3K/Akt Pathway.circFOXO3 通过调控 PI3K/Akt 通路对肝癌细胞增殖和侵袭的影响。
Contrast Media Mol Imaging. 2022 Jul 14;2022:2109908. doi: 10.1155/2022/2109908. eCollection 2022.

本文引用的文献

1
Mechanisms and consequences of endothelial cell senescence.内皮细胞衰老的机制和后果。
Nat Rev Cardiol. 2023 Jan;20(1):38-51. doi: 10.1038/s41569-022-00739-0. Epub 2022 Jul 19.
2
Circular RNAs: Characterization, cellular roles, and applications.环状RNA：特征、细胞功能及应用
Cell. 2022 Jun 23;185(13):2390. doi: 10.1016/j.cell.2022.06.001.
3
rs12196996, a polymorphism at the gene flanking intron, is associated with circFOXO3 levels and the risk of coronary artery disease.rs12196996 是位于基因侧翼内含子的一个多态性，与 circFOXO3 水平和冠心病风险相关。
Aging (Albany NY). 2020 Jul 2;12(13):13076-13089. doi: 10.18632/aging.103398.
4
Endothelial cell transitions.内皮细胞转变
Science. 2018 Nov 16;362(6416):746-747. doi: 10.1126/science.aas9432.
5
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.异质性核糖核蛋白K：一种HDM2靶点及p53在DNA损伤应答中的转录共激活因子。
Cell. 2005 Dec 16;123(6):1065-78. doi: 10.1016/j.cell.2005.09.032.