Zhang Lei, Wang Yin, Zhang Yuan, Zhao Yanfang, Li Peifeng
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, NO38 DengZhou Road, Qingdao 266021, China.
Institute of Biomedical Research, School for Life Science, Shandong University of Technology, 266 Xincun West Road, Zibo 255000, China.
Mol Ther Nucleic Acids. 2021 Jan 20;23:908-917. doi: 10.1016/j.omtn.2021.01.010. eCollection 2021 Mar 5.
Circular RNAs (circRNAs) are covalently closed circular structures that can function in various physiological and pathological processes by acting as microRNA (miRNA) sponges, RNA-binding protein (RBP) sponges, mRNA transcriptional regulators, and protein translational templates. circFoxo3 is one of the most studied circRNAs and is generated from the tumor suppressor gene . Increasing studies have demonstrated the multiple functions of circFoxo3 in the pathogenesis of different cancer types. circFoxo3 plays important roles in cancer development mainly by binding to various miRNAs. The diagnostic potential of circFoxo3 has been revealed in several cancers. Some research results have been found to contradict the results of other studies, and this may be due to insufficient sample sizes and inconsistencies in the experimental and nomenclature methods. In this review, we systematically summarize current knowledge about the biogenesis and functions of circRNAs, elucidate the roles of circFoxo3 in different cancers, and explore the clinical applications of circFoxo3.
环状RNA（circRNAs）是共价闭合的环状结构，可通过充当微小RNA（miRNA）海绵、RNA结合蛋白（RBP）海绵、mRNA转录调节因子和蛋白质翻译模板，在各种生理和病理过程中发挥作用。circFoxo3是研究最多的circRNAs之一，由肿瘤抑制基因产生。越来越多的研究表明circFoxo3在不同癌症类型的发病机制中具有多种功能。circFoxo3主要通过与各种miRNA结合在癌症发展中发挥重要作用。circFoxo3在几种癌症中已显示出诊断潜力。一些研究结果与其他研究结果相矛盾，这可能是由于样本量不足以及实验和命名方法不一致所致。在本综述中，我们系统地总结了关于circRNAs生物发生和功能的当前知识，阐明了circFoxo3在不同癌症中的作用，并探讨了circFoxo3的临床应用。
