Tian Yuan, Zhang Dan, Yang Huaian, Zhang Xiaoli, Xu Shengqun
Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China.
J Pharm Anal. 2025 May;15(5):101251. doi: 10.1016/j.jpha.2025.101251. Epub 2025 Mar 1.
Endothelial dysfunction is a key factor linking obstructive sleep apnea hypopnea syndrome (OSAHS) with cardiovascular diseases. In this study, we used advanced proteomics and metabolomics approaches to investigate the impact of extracellular vesicles (EVs) derived from the serum of OSAHS patients on endothelial function. Our multi-omics analysis identified dysregulated pathways related to fatty acid metabolism, apoptosis regulation, and inflammatory responses, highlighting fatty acid synthase (FASN) as a crucial player in OSAHS-induced endothelial dysfunction. Both and experiments demonstrated that FASN-enriched EVs impair endothelial cell viability and disrupt metabolic homeostasis, offering new insights for the development of targeted therapies for cardiovascular complications associated with OSAHS.
内皮功能障碍是阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与心血管疾病之间联系的关键因素。在本研究中，我们使用先进的蛋白质组学和代谢组学方法，研究源自OSAHS患者血清的细胞外囊泡（EVs）对内皮功能的影响。我们的多组学分析确定了与脂肪酸代谢、细胞凋亡调节和炎症反应相关的失调通路，突出了脂肪酸合酶（FASN）在OSAHS诱导的内皮功能障碍中的关键作用。体外和体内实验均表明，富含FASN的EVs损害内皮细胞活力并破坏代谢稳态，为开发针对与OSAHS相关的心血管并发症的靶向治疗提供了新见解。
