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富含脂肪酸合酶的细胞外囊泡对阻塞性睡眠呼吸暂停低通气综合征中内皮细胞功能的影响。

Impact of FASN-enriched EVs on endothelial cell function in obstructive sleep apnea hypopnea syndrome.

作者信息

Tian Yuan, Zhang Dan, Yang Huaian, Zhang Xiaoli, Xu Shengqun

机构信息

Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Department of Pediatrics, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, 110004, China.

出版信息

J Pharm Anal. 2025 May;15(5):101251. doi: 10.1016/j.jpha.2025.101251. Epub 2025 Mar 1.

DOI:10.1016/j.jpha.2025.101251
PMID:40521370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12166414/
Abstract

Endothelial dysfunction is a key factor linking obstructive sleep apnea hypopnea syndrome (OSAHS) with cardiovascular diseases. In this study, we used advanced proteomics and metabolomics approaches to investigate the impact of extracellular vesicles (EVs) derived from the serum of OSAHS patients on endothelial function. Our multi-omics analysis identified dysregulated pathways related to fatty acid metabolism, apoptosis regulation, and inflammatory responses, highlighting fatty acid synthase (FASN) as a crucial player in OSAHS-induced endothelial dysfunction. Both and experiments demonstrated that FASN-enriched EVs impair endothelial cell viability and disrupt metabolic homeostasis, offering new insights for the development of targeted therapies for cardiovascular complications associated with OSAHS.

摘要

内皮功能障碍是阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与心血管疾病之间联系的关键因素。在本研究中，我们使用先进的蛋白质组学和代谢组学方法，研究源自OSAHS患者血清的细胞外囊泡（EVs）对内皮功能的影响。我们的多组学分析确定了与脂肪酸代谢、细胞凋亡调节和炎症反应相关的失调通路，突出了脂肪酸合酶（FASN）在OSAHS诱导的内皮功能障碍中的关键作用。体外和体内实验均表明，富含FASN的EVs损害内皮细胞活力并破坏代谢稳态，为开发针对与OSAHS相关的心血管并发症的靶向治疗提供了新见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/c1d92d1631dd/gr8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/f5ffd5f148ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/5553d1cbb44c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/c15282bec808/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/d68eb636fbbc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/32626782e225/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/475877b2995e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/149141163e03/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/c1d92d1631dd/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/5961f5a48aec/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/f5ffd5f148ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/5553d1cbb44c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/c15282bec808/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/d68eb636fbbc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/32626782e225/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/475877b2995e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/149141163e03/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2964/12166414/c1d92d1631dd/gr8.jpg

相似文献

[1]
Impact of FASN-enriched EVs on endothelial cell function in obstructive sleep apnea hypopnea syndrome.

J Pharm Anal. 2025-5

[2]
Therapeutic role of adipose-derived mesenchymal stem cells-derived extracellular vesicles in rats with obstructive sleep apnea hypopnea syndrome.

Regen Ther. 2023-3-1

[3]
Serum adropin level is associated with endothelial dysfunction in patients with obstructive sleep apnea and hypopnea syndrome.

Sleep Breath. 2021-3

[4]
Evaluation of nocturnal apnea and airflow limitation as indicators for cognitive dysfunction in patients with chronic obstructive pulmonary disease/obstructive sleep apnea hypopnea syndrome overlap syndrome.

Chron Respir Dis. 2024

[5]
[Study of the occurrence of metabolic dysfunction-associated fatty liver disease in obstructive sleep apnea hypopnea syndrome and its risk factors].

Zhonghua Nei Ke Za Zhi. 2025-2-1

[6]
Metabolomic profiles predict clinical severity in patients with obstructive sleep apnea-hypopnea syndrome.

J Clin Sleep Med. 2024-9-1

[7]
White matter lesions are associated with obstructive sleep apnea hypopnea syndrome.

Neurol Res. 2022-5

[8]
Serum periostin and TNF-α levels in patients with obstructive sleep apnea-hypopnea syndrome.

Sleep Breath. 2021-3

[9]
Correlation between cognitive impairment and serum markers in patients with obstructive sleep apnea-hypopnea syndrome.

Sleep Breath. 2024-5

[10]
Correlation between obstructive sleep apnea hypopnea syndrome and hypertension: a systematic review and meta-analysis.

Ann Palliat Med. 2021-12

本文引用的文献

[1]
FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress.

Cell Rep. 2023-8-29

[2]
The role of extracellular vesicles in cancer.

Cell. 2023-4-13

[3]
Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon-bone healing.

J Nanobiotechnology. 2023-1-16

[4]
Glycolysis and de novo fatty acid synthesis cooperatively regulate pathological vascular smooth muscle cell phenotypic switching and neointimal hyperplasia.

J Pathol. 2023-4

[5]
Obstructive sleep apnea-hypopnea syndrome complicated with idiopathic intracranial hypertension: a case report.

Ann Palliat Med. 2022-12

[6]
Eukaryotic initiation factor 6 repression mitigates atherosclerosis progression by inhibiting macrophages expressing Fasn.

IUBMB Life. 2023-5

[7]
Research progress on the role of exosomes in obstructive sleep apnea-hypopnea syndrome-related atherosclerosis.

Sleep Med Rev. 2022-12

[8]
The correlation of serum/plasma IGF-1 concentrations with obstructive sleep apnea hypopnea syndrome: A meta-analysis and meta-regression.

Front Endocrinol (Lausanne). 2022

[9]
p53 Promotes Ferroptosis in Macrophages Treated with FeO Nanoparticles.

ACS Appl Mater Interfaces. 2022-9-28

[10]
Loss of Sirtuin 1 (SIRT1) potentiates endothelial dysfunction via impaired glycolysis during infectious challenge.

Clin Transl Med. 2022-9

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