Wang Huizhu, Zhang Miao, Chen Ying, Ding Shaopei, Qin Meng, Wu Tong, Li Jianshu, Xie Jing
College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu, 610065, P. R. China.
Sichuan Eye Hospital, AIER Eye Hospital Group, No. 153, Tianfu Fourth Street, High-tech Zone, Chengdu, 610047, P. R. China.
J Mater Chem B. 2025 Jul 10;13(27):8026-8037. doi: 10.1039/d5tb00704f.
Osteoarthritis (OA) is a degenerative bone and joint disease characterized by cartilage degradation and an inflammatory environment. Consequently, strategies aimed at remodeling the damaged joint microenvironment by concurrently enhancing lubrication and alleviating inflammation are essential for improving therapeutic efficacy. Herein, we designed multifunctional cyclic brush polymer (CP) nanomicelles composed of surface-grafted zwitterionic poly(sulfobetaine methacrylate) (PSBMA) brushes and a hydrophobic core of PHEMA. Benefiting from the unique cyclic brush topology and hydrated lubrication properties of PSBMA, the CPs exhibited effective lubrication. Tribological and wear tests showcased the CPs significantly reduced the coefficient of friction and surface wear under shear forces. Furthermore, the CPs served as nanocarriers for encapsulating the anti-inflammatory drug resveratrol (RSV) through hydrophobic interactions, serving as drug-loaded nanomicelles CP@RSV. studies indicated that CP@RSV exhibited excellent cytocompatibility, effectively eliminated reactive oxygen species (ROS) in cells and reversed mitochondrial dysfunction, thereby modulating the oxidative stress microenvironment. In conclusion, CP@RSV integrates enhanced lubrication with antioxidation properties, representing a promising strategy for the treatment of OA.
骨关节炎（OA）是一种以软骨退化和炎症环境为特征的退行性骨和关节疾病。因此，通过同时增强润滑和减轻炎症来重塑受损关节微环境的策略对于提高治疗效果至关重要。在此，我们设计了由表面接枝两性离子聚（甲基丙烯酸磺酸甜菜碱）（PSBMA）刷和聚甲基丙烯酸2-羟乙酯（PHEMA）疏水核组成的多功能环状刷状聚合物（CP）纳米胶束。受益于PSBMA独特的环状刷拓扑结构和水合润滑性能，CP表现出有效的润滑作用。摩擦学和磨损测试表明，CP在剪切力作用下显著降低了摩擦系数和表面磨损。此外，CP作为纳米载体，通过疏水相互作用包裹抗炎药物白藜芦醇（RSV），形成载药纳米胶束CP@RSV。研究表明，CP@RSV表现出优异的细胞相容性，有效消除细胞内的活性氧（ROS）并逆转线粒体功能障碍，从而调节氧化应激微环境。总之，CP@RSV将增强的润滑作用与抗氧化性能相结合，代表了一种治疗OA的有前景的策略。
