Haimovich J, Bergman Y, Linker-Israeli M, Haran-Ghera N
Eur J Immunol. 1977 Apr;7(4):226-30. doi: 10.1002/eji.1830070408.
Preleukemic cells could be detected in the bone marrow cell population of SJL/J mice within several days after induction of leukemia by repeated feedings with a chemical carcinogen 7,12-dimethylbenz[a]anthracene (DMBA). Bone marrow cells collected 7, 30 or 60 days following carcinogenic treatment, developed lymphoid tumors upon transplantation into syngeneic irradiated recipients. The incidence of these tumors varied between 40--45% when the bone marrow cells were collected and transferred 7--30 days after feeding with DMBA, and raised to an incidence of 80% when transferred 60 days after carcinogen administration (compared to 50% incidence in the DMBA-treated bone marrow donors). A survey of several cell surface components on the lymphoid tumor cells, obtained after transplantation of preleukemic cells, indicated that most of the tumor lines bore both the Thy-1.2 antigen (weak) and the Fc receptor, whereas the rest were positive only for the Fc receptor. None of these tumor cell lines would yield a significant amount of cell-bound immunoglobulin.
在用化学致癌物7,12-二甲基苯并[a]蒽（DMBA）反复喂食诱导白血病后的几天内，可在SJL/J小鼠的骨髓细胞群体中检测到白血病前期细胞。致癌处理后7、30或60天收集的骨髓细胞，移植到同基因受辐照受体中后会发展为淋巴瘤。当在喂食DMBA后7至30天收集并转移骨髓细胞时，这些肿瘤的发生率在40%-45%之间，而在致癌物给药后60天转移时，发生率提高到80%（相比之下，DMBA处理的骨髓供体的发生率为50%）。对白血病前期细胞移植后获得的淋巴瘤细胞上的几种细胞表面成分进行的一项调查表明，大多数肿瘤系同时带有Thy-1.2抗原（弱阳性）和Fc受体，而其余的仅对Fc受体呈阳性。这些肿瘤细胞系均不会产生大量细胞结合免疫球蛋白。
