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[眼部酒渣鼻:临床症状、诊断、管理与治疗]

[Ocular rosacea : Clinical aspects, diagnostics, management and treatment].

作者信息

Partzsch Louise, Nguyen Katrin, Korsing Sören, Pleyer Uwe

机构信息

Augenklinik Campus Virchow Klinikum - Universitätsmedizin Berlin Charité, Universitätsmedizin Berlin, Freie Universität Berlin und Humboldt-Universität zu Berlin, Berlin, Deutschland.

Dermatologie Campus Virchow Klinikum, Universitätsmedizin Berlin Charité, Universitätsmedizin Berlin, Freie Universität Berlin und Humboldt-Universität zu Berlin, Berlin, Deutschland.

出版信息

Ophthalmologie. 2025 Jun 16. doi: 10.1007/s00347-025-02265-z.

DOI:10.1007/s00347-025-02265-z
PMID:40522449
Abstract

Ocular rosacea is a chronic inflammatory disease that affects the surface of the eye and the eyelids. It often occurs in conjunction with rosacea in the facial area but can also occur independently. It is characterized by bilateral chronic posterior blepharitis and meibomitis, which can involve the entire surface of the eye, including the cornea, during the course of the disease. The diagnosis is largely based on clinical findings. The main symptoms include reddened, burning and itchy eyes, dryness, sensitivity to light and blurred vision. The exact etiology of ocular rosacea is not fully understood. A genetic predisposition, dysregulation of the immune system, environmental factors and microbial factors are involved. Treatment usually includes a combination of eyelid hygiene, topical and, if necessary, systemic agents. The prognosis is generally considered favorable; however, in the case of untreated ocular rosacea, severe progressive courses can also lead to blindness.

摘要

眼部酒渣鼻是一种影响眼表和眼睑的慢性炎症性疾病。它常与面部酒渣鼻同时出现,但也可单独发生。其特征为双侧慢性睑缘炎和睑板腺炎,在疾病过程中可累及眼的整个表面,包括角膜。诊断主要基于临床表现。主要症状包括眼睛发红、灼痛、瘙痒、干涩、畏光和视力模糊。眼部酒渣鼻的确切病因尚未完全明确。涉及遗传易感性、免疫系统失调、环境因素和微生物因素。治疗通常包括眼睑清洁、局部用药,必要时全身用药。总体预后通常较好;然而,未经治疗的眼部酒渣鼻严重进展时也可导致失明。

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1
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Ophthalmologie. 2025 Jun 16. doi: 10.1007/s00347-025-02265-z.
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本文引用的文献

1
Rosacea in childhood and adolescence: A review.儿童和青少年酒渣鼻:综述
J Dtsch Dermatol Ges. 2025 Jun;23(6):684-691. doi: 10.1111/ddg.15693. Epub 2025 Mar 22.
2
Exploring the psychodermatologic burden and associated psychiatric manifestations in rosacea: a systemic review.探讨酒渣鼻的心理皮肤病负担及相关精神症状:一项系统评价。
Arch Dermatol Res. 2025 Feb 15;317(1):427. doi: 10.1007/s00403-025-03982-w.
3
Treatment of ocular rosacea: a systematic review.眼玫瑰痤疮的治疗:系统评价。
J Dtsch Dermatol Ges. 2024 Feb;22(2):167-174. doi: 10.1111/ddg.15290. Epub 2024 Jan 20.
4
Diagnosis and Treatment of Morbihan's Disease: A Practical Approach based on Review of the Literature.莫尔比昂病的诊断与治疗:基于文献综述的实用方法
J Clin Aesthet Dermatol. 2023 Oct;16(10):22-30.
5
Prospective evaluation of intense pulsed light treatment for meibomian gland dysfunction and blepharitis due to ocular rosacea.前瞻性评估强脉冲光治疗因眼红斑痤疮导致的睑板腺功能障碍和睑缘炎。
Eur J Dermatol. 2022 Jul 1;32(4):505-515. doi: 10.1684/ejd.2022.4301.
6
Clinical clues to identify patients with ocular rosacea - a Germany-wide epidemiologic analysis.识别眼型酒渣鼻患者的临床线索——一项德国范围的流行病学分析。
Int J Dermatol. 2022 Jul;61(7):880-885. doi: 10.1111/ijd.16235. Epub 2022 May 17.
7
Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea: A Systematic Review and Meta-analysis.评估玫瑰痤疮患者各亚型的频率:系统评价和荟萃分析。
JAMA Dermatol. 2022 Jun 1;158(6):617-625. doi: 10.1001/jamadermatol.2022.0526.
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[Not Available].[不可用]。
J Dtsch Dermatol Ges. 2022 Feb;20(2):185-204. doi: 10.1111/ddg.14683_g.
9
Association of rosacea with depression and anxiety: A systematic review and meta-analysis.玫瑰痤疮与抑郁和焦虑的相关性:系统评价和荟萃分析。
J Affect Disord. 2022 Feb 15;299:239-245. doi: 10.1016/j.jad.2021.12.008. Epub 2021 Dec 5.
10
Ocular Comorbidities in Rosacea: A Case-Control Study Based on Seven Institutions.酒渣鼻的眼部合并症:一项基于七家机构的病例对照研究
J Clin Med. 2021 Jun 29;10(13):2897. doi: 10.3390/jcm10132897.