Kellner Christiane, Ceanga Mihai, Leicht Jakob, Kühnel Christian, Piramoon Mina, Kloos Christof, Müller Nicolle, Wolf Gunter
Klinik für Innere Medizin III, FB Endokrinologie und Stoffwechselerkrankungen, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.
Klinik für Neurologie, Universitätsklinikum Jena, Jena, Deutschland.
Inn Med (Heidelb). 2025 Jun 16. doi: 10.1007/s00108-025-01919-z.
At 1.5 years after the diagnosis of glutamate decarboxylase(GAD)-associated encephalitis (highly positive GAD antibodies in cerebrospinal fluid and serum) in a 72-year-old patient, hyperglycemia above 40 mmol/l was the cause of progressive neurological symptoms. GAD is an important enzyme in the central nervous system and pancreatic β‑cells that convert L‑glutamate into γ‑aminobutyric acid (GABA). High GAD antibodies are associated with autoimmune diseases such as encephalitis and diabetes mellitus type 1, requiring interdisciplinary diagnostics and therapy.
一名72岁患者被诊断为谷氨酸脱羧酶（GAD）相关脑炎（脑脊液和血清中GAD抗体高度阳性）1.5年后，血糖高于40 mmol/l是其进行性神经症状的病因。GAD是中枢神经系统和胰腺β细胞中的一种重要酶，可将L-谷氨酸转化为γ-氨基丁酸（GABA）。高GAD抗体与脑炎和1型糖尿病等自身免疫性疾病有关，需要多学科诊断和治疗。
