1α-羟基维生素D2对糖皮质激素处理大鼠钙代谢的影响。

The effect of 1 alpha-hydroxyvitamin D2 on calcium metabolism in glucocorticoid-treated rats.

作者信息

Sjödén G O, Lindgren J U, DeLuca H F

出版信息

Bone. 1985;6(4):231-4. doi: 10.1016/8756-3282(85)90005-5.

Abstract

Intestinal calcium transport and renal calcium and phosphate excretion have been measured in normal and prednisolone-treated rats. Prednisolone treatment reduced intestinal calcium transport and increased phosphate excretion, causing a reduction in serum phosphate. Both 1 alpha-hydroxyvitamin D2 and 1 alpha-hydroxyvitamin D3 normalized phosphate excretion, whereas 1 alpha-hydroxyvitamin D3 was not fully effective in serum phosphate. Prednisolone treatment also caused a decreased bone density that was prevented both with 1 alpha-hydroxyvitamin D2 and 1 alpha-hydroxyvitamin D3. 1 alpha-hydroxyvitamin D2 appeared at least as effective as 1 alpha-hydroxyvitamin D3 in correcting the bone disturbance.

摘要

已对正常大鼠和经泼尼松龙治疗的大鼠的肠道钙转运以及肾脏钙和磷酸盐排泄进行了测量。泼尼松龙治疗降低了肠道钙转运并增加了磷酸盐排泄，导致血清磷酸盐减少。1α-羟基维生素D2和1α-羟基维生素D3均使磷酸盐排泄恢复正常，而1α-羟基维生素D3对血清磷酸盐的作用不完全有效。泼尼松龙治疗还导致骨密度降低，而1α-羟基维生素D2和1α-羟基维生素D3均可预防这种情况。在纠正骨骼紊乱方面，1α-羟基维生素D2似乎至少与1α-羟基维生素D3一样有效。