Mercer R R, Crenshaw M A
Bone. 1985;6(4):269-74. doi: 10.1016/8756-3282(85)90010-9.
It has been suggested that osteocytes may resorb bone during the calcium mobilization that occurs during lactation. To test this hypothesis morphometric methods were used to evaluate changes in mature nonmated female rats, 6-day postpartum nonlactating rats, 21-day postpartum nonlactating rats, 6-day lactating rats, 15-day lactating rats, and 21-day lactating rats using femur cross sections in the diaphyseal region. Osteoclast resorption per unit length of periosteal surface, as well as other measures of resorption activity, demonstrated that by 15 days of lactation a significant mobilization of calcium was occurring. The volume density of osteocyte lacunae and individual lacunar volumes from serial section reconstruction showed no increase in the lactating groups. Indeed, the only significant change in lacunae volume was a decrease apparently due to pregnancy. It is concluded from this study that osteocytes do not resorb bone during lactation.
有人提出，在哺乳期发生的钙动员过程中，骨细胞可能会吸收骨组织。为了验证这一假设，采用形态计量学方法，利用骨干区域的股骨横截面，对未交配的成熟雌性大鼠、产后6天的非泌乳大鼠、产后21天的非泌乳大鼠、泌乳6天的大鼠、泌乳15天的大鼠和泌乳21天的大鼠的变化进行评估。骨膜表面单位长度的破骨细胞吸收以及其他吸收活性指标表明，到泌乳第15天时，钙的动员量显著增加。通过连续切片重建得到的骨细胞陷窝体积密度和单个陷窝体积显示，泌乳组没有增加。实际上，陷窝体积唯一显著的变化是由于怀孕导致的明显减少。从这项研究得出的结论是，哺乳期骨细胞不会吸收骨组织。
