Department of Medicine, University of California at Davis Medical Center Sacramento, CA 95818, USA.
Bone. 2013 Jun;54(2):279-84. doi: 10.1016/j.bone.2013.01.034. Epub 2013 Jan 26.
Glucocorticoids are used for the treatment of inflammatory and autoimmune diseases. While they are effective therapy, bone loss and incident fracture risk are high. While previous studies have found GC effects on both osteoclasts and osteoblasts, our work has focused on the effects of GCs on osteocytes. Osteocytes exposed to low dose GCs undergo autophagy while osteocytes exposed to high doses of GCs or for a prolonged period of time undergo apoptosis.
糖皮质激素用于治疗炎症性和自身免疫性疾病。虽然它们是有效的治疗方法，但骨丢失和骨折风险增加。虽然之前的研究发现 GC 对破骨细胞和成骨细胞都有影响，但我们的工作重点是 GC 对骨细胞的影响。暴露于低剂量 GC 的骨细胞会发生自噬，而暴露于高剂量 GC 或长时间暴露于 GC 的骨细胞会发生细胞凋亡。
