Wu Qiang, Chen Hongyu, Huang Biaohong, Hu Weijin, Wang Yi, Li Shujun, Tao Yushun, Jiang Xu, Dai Kerong, Jiao Yilai, Wang Liao
Shanghai Key Laboratory of Orthopedic Implants, Clinical and Translational Research Center for 3D Printing Technology, Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang, 110016, China.
ACS Appl Mater Interfaces. 2025 Jul 2;17(26):37548-37561. doi: 10.1021/acsami.5c04997. Epub 2025 Jun 16.
Barium titanate (BaTiO) is a conventional piezoelectric material, but its biocompatibility is limited. Besides, its piezoelectric property is significantly different from that of natural bone tissue. To address this, we have developed an innovative coating material that mimics the piezoelectric characteristics of natural bone with a coefficient of 7.8 pm/V. The material was fabricated by replacing titanium (Ti) in the BaTiO crystal lattice with copper (Cu), a strategy that not only augments the piezoelectric response but also harnesses the osteogenic potential of Cu. BaCuTiO reveals an enhanced piezoelectric performance and actively promotes the adhesion, proliferation, and differentiation of MC3T3-E1 cells. Moreover, doped Cu modulates osteogenic differentiation through the upregulation of the Wnt4/β-catenin/SP7/Osterix signaling pathway. The synergistical effect caused by piezoelectricity and the biological activity of Cu contributed to promoting bone regeneration in vivo; in particular, H-BaCuTiO led to a 15.6% increase of the bone volume percentage compared to BaTiO. Furthermore, H-BaCuTiO promoted the accumulation of bone extracellular matrix components including Osteopontin (OPN) and Collagen Type I (COL-1), which, respectively, increased by 62.12 and 155%. The synergistic interplay between the piezoelectric property of BaCuTiO and the osteogenic influence of Cu has significantly improved the repairing process of bone defects, offering a promising advancement in the field of orthopedic implant coatings.
钛酸钡（BaTiO）是一种传统的压电材料，但其生物相容性有限。此外，其压电性能与天然骨组织有显著差异。为了解决这个问题，我们开发了一种创新的涂层材料，它模拟了天然骨的压电特性，系数为7.8皮米/伏。该材料是通过用铜（Cu）取代BaTiO晶格中的钛（Ti）来制备的，这一策略不仅增强了压电响应，还利用了Cu的成骨潜力。BaCuTiO显示出增强的压电性能，并积极促进MC3T3-E1细胞的粘附、增殖和分化。此外，掺杂的Cu通过上调Wnt4/β-连环蛋白/SP7/osterix信号通路来调节成骨分化。压电性和Cu的生物活性所产生的协同效应有助于促进体内骨再生；特别是，与BaTiO相比，H-BaCuTiO使骨体积百分比增加了15.6%。此外，H-BaCuTiO促进了包括骨桥蛋白（OPN）和I型胶原蛋白（COL-1）在内的骨细胞外基质成分的积累，分别增加了62.12%和155%。BaCuTiO的压电性能与Cu的成骨影响之间的协同相互作用显著改善了骨缺损的修复过程，为骨科植入物涂层领域提供了一个有前景的进展。
