Hu Ying, Li Mingjun, Xu Xun, Ma Nan, Luo Jiahao, Wu Xiaoxuan, Ping Qixiang, Lin Xiao, Zhang Tingbin, Liang Chunyong, Yang Lei
Center for Health Science and Engineering, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China.
Institute of Active Polymers and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Hereon, Kantstr. 55, 14513 Teltow, Germany.
J Mater Chem B. 2025 Jun 18;13(24):7014-7023. doi: 10.1039/d5tb00211g.
Prosthetic joint infection (PJI) remains a significant challenge in clinical applications. It not only impedes the recovery of bone tissue at the site of bone defect but also leads to multiple debridements, long-lasting antibiotic treatment and even secondary replacement. Titanium alloy Ti6Al4V (TC4) is widely used in orthopedic implants due to its excellent mechanical properties and biocompatibility; however, it lacks inherent antibacterial and osteoinductive functions. In this study, a composite coating based on polyvinyl alcohol (PVA) with tissue repair and antibacterial properties was applied on the surface of TC4. A PVA gel coating functionalized with terpyridine and catechol groups (PVA-TP-CA) was synthesized and subsequently complexed with copper (Cu) ions. The differential binding affinities of TP and CA groups to Cu enabled a sustained and controlled release of metal ions. Furthermore, a micro-nano surface structure was fabricated on TC4 using femtosecond laser technology to achieve a micro-nano structure interface and enhanced bonding strength. Biological evaluations demonstrated that the modified surface significantly improved the antibacterial, angiogenic, and osteogenic properties of TC4. These findings indicate that this multifunctional composite coating holds great promise for surface modification of orthopedic implants, offering an effective strategy for preventing PJI while promoting bone regeneration.
人工关节感染（PJI）在临床应用中仍然是一个重大挑战。它不仅阻碍骨缺损部位骨组织的恢复，还会导致多次清创、长期抗生素治疗甚至二次置换。钛合金Ti6Al4V（TC4）因其优异的机械性能和生物相容性而广泛应用于骨科植入物；然而，它缺乏固有的抗菌和骨诱导功能。在本研究中，一种基于聚乙烯醇（PVA）的具有组织修复和抗菌性能的复合涂层被应用于TC4表面。合成了一种用三联吡啶和儿茶酚基团功能化的PVA凝胶涂层（PVA-TP-CA），随后与铜（Cu）离子络合。TP和CA基团对Cu的不同结合亲和力使得金属离子能够持续、可控地释放。此外，利用飞秒激光技术在TC4上制备了微纳表面结构，以实现微纳结构界面并提高结合强度。生物学评估表明，改性表面显著改善了TC4的抗菌、促血管生成和成骨性能。这些发现表明，这种多功能复合涂层在骨科植入物表面改性方面具有巨大潜力，为预防PJI同时促进骨再生提供了一种有效策略。
