Finegan J A, Quarrington B J, Hughes H E, Rudd N L, Stevens L J, Weksberg R, Doran T A
Br J Obstet Gynaecol. 1985 Oct;92(10):1015-23. doi: 10.1111/j.1471-0528.1985.tb02996.x.
Ninety-one infants whose mothers had had amniocentesis, because age increased their risk for a fetal chromosome abnormality, were compared with 53 infants whose mothers chose not to have the test. Mental and motor development and temperament were studied to assess potential influence of amniocentesis on the brain. Physical growth was assessed and the infants were examined for orthopaedic abnormalities and needle injury. The results indicated that amniocentesis does not appear to influence infant mental and motor development, temperament, physical growth or the risk of orthopaedic abnormalities. However, amniocentesis is not entirely free of risk because several of the infants had needle marks. Reassessment of the cohort at age 4 and 7 years and will provide information on the potential longer term consequences of mid-trimester amniocentesis.
对91名母亲因年龄增加胎儿染色体异常风险而进行羊膜穿刺术的婴儿，与53名母亲选择不进行该项检查的婴儿进行了比较。研究了智力和运动发育以及气质，以评估羊膜穿刺术对大脑的潜在影响。评估了身体生长情况，并对婴儿进行了骨科异常和针刺损伤检查。结果表明，羊膜穿刺术似乎不会影响婴儿的智力和运动发育、气质、身体生长或骨科异常风险。然而，羊膜穿刺术并非完全没有风险，因为有几名婴儿有针痕。对该队列在4岁和7岁时进行重新评估，将提供关于孕中期羊膜穿刺术潜在长期后果的信息。
