Finegan J A, Quarrington B J, Hughes H E, Mervyn J M, Hood J E, Zacher J E, Boyden M
Hospital for Sick Children, Department of Psychology, Toronto, Ontario, Canada.
Br J Obstet Gynaecol. 1990 Jan;97(1):32-40. doi: 10.1111/j.1471-0528.1990.tb01713.x.
Four-year-old children whose mothers had mid-trimester amniocentesis (n = 88) were compared with children whose mothers chose not to have the procedure (n = 46). Intelligence, visual-motor-perceptual skills, language, behaviour, social competence, temperament, physical growth, hearing, and middle-ear function were measured using standardized procedures. Health histories were obtained by maternal report. The results suggest that the wide range of developmental and behavioural variables studied is not influenced by removal of amniotic fluid in the mid-trimester. However, mothers who had amniocentesis were more likely to report a history of ear infections in their child (P = 0.04). In support of this finding were the results of audiological assessment which demonstrated a trend toward a higher rate of bilateral middle-ear impedance abnormalities in children whose mothers had amniocentesis (P = 0.06). Further study of the upper respiratory system is recommended to explore potential long-term sequelae of mid-trimester amniocentesis.
将母亲在孕中期接受羊膜穿刺术的4岁儿童（n = 88）与母亲选择不接受该手术的儿童（n = 46）进行了比较。使用标准化程序测量智力、视觉运动感知技能、语言、行为、社会能力、气质、身体发育、听力和中耳功能。通过母亲报告获取健康史。结果表明，所研究的广泛发育和行为变量不受孕中期羊水抽取的影响。然而，接受羊膜穿刺术的母亲更有可能报告其孩子有耳部感染史（P = 0.04）。听力评估结果支持了这一发现，该结果表明，母亲接受羊膜穿刺术的儿童双侧中耳阻抗异常发生率有升高趋势（P = 0.06）。建议对上呼吸道系统进行进一步研究，以探索孕中期羊膜穿刺术潜在的长期后遗症。
