Elston J S, Lee J P, Powell C M, Hogg C, Clark P
Br J Ophthalmol. 1985 Oct;69(10):718-24. doi: 10.1136/bjo.69.10.718.
Eighty-five adults with horizontal concomitant strabismus were treated with an injection of a low dose of botulinum toxin A (BTXA) into the lateral or medial rectus muscle. The ocular deviation was reduced by an average of 60% independently of its size and whether or not surgery had previously been performed. The change was temporary, however, except in those cases with binocular functions, when fusion was re-established. Repeated low dose injections can maintain the improvement, but at higher doses, although larger reductions are produced, temporary local side effects--ptosis and vertical strabismus--are common. The technique is simple, well tolerated, and has no systemic side effects.
85例水平共同性斜视的成人患者接受了低剂量A型肉毒杆菌毒素（BTXA）注射到外直肌或内直肌的治疗。无论斜视的大小以及之前是否接受过手术，眼位偏斜平均减少了60%。然而，这种变化是暂时的，除非是那些具有双眼功能且重新建立了融合的病例。重复低剂量注射可以维持改善效果，但高剂量时，虽然能产生更大程度的减少，但暂时的局部副作用——上睑下垂和垂直斜视——很常见。该技术操作简单，耐受性良好，且无全身副作用。
