麻痹性斜视：肉毒杆菌毒素的作用
Paralytic strabismus: the role of botulinum toxin.
作者信息
Elston J S, Lee J P
出版信息
Br J Ophthalmol. 1985 Dec;69(12):891-6. doi: 10.1136/bjo.69.12.891.
Abstract
Five adults with acute extraocular muscle palsies followed by limited recovery of muscle function were treated with injections of botulinum toxin A to the ipsilateral antagonist of the affected muscle. Three were cases of unilateral sixth nerve palsy, one of bilateral sixth nerve palsy, and one of third nerve palsy. After a period of paralysis, during which the strabismus was overcorrected, the injected muscle recovered and binocular sensory and motor functions were restored and have been maintained for periods of up to 21 months. The treatment is a safe and effective alternative to surgery, particularly in cases in which a general anaesthetic is not advisable.
摘要
五名患有急性眼外肌麻痹且肌肉功能恢复有限的成年人接受了向患侧肌肉同侧拮抗肌注射A型肉毒杆菌毒素的治疗。其中3例为单侧第六神经麻痹，1例为双侧第六神经麻痹，1例为第三神经麻痹。经过一段时间的麻痹，在此期间斜视得到过度矫正，注射的肌肉恢复，双眼感觉和运动功能得以恢复并维持了长达21个月的时间。该治疗是一种安全有效的手术替代方法，尤其适用于不宜进行全身麻醉的病例。
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2
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