Pauciulo Claudia, Uccheddu Stefania, Corda Andrea, Biggio Federica, Corlazzoli Daniele Sebastian, Menchetti Marika, Gallucci Antonella
Veterinary Neurology Center, Rome, Italy.
Behavioral Medicine and Animal Welfare Division, San Marco Veterinary Clinic and Laboratory, Veggiano, Italy.
J Vet Intern Med. 2025 Jul-Aug;39(4):e70174. doi: 10.1111/jvim.70174.
Hyperesthesia syndrome (HS) is a common yet poorly understood condition in cats, with hypothesized neurological and behavioral causes and limited data on outcomes and treatment.
This study aimed to describe the clinical outcomes and the treatment response of 28 cats with HS, managed through various therapeutic strategies.
Clinical records of 28 cats with HS and minimum of 1-year follow-up were reviewed.
Retrospective, observational, descriptive study conducted on a case series of cats affected by HS. Sixteen cats (57%) received fluoxetine alone (Fluoxetine-only), seven (25%) were managed with behavioral modification and gabapentin or fluoxetine (Fluoxetine/Gabapentin + Behavior) and five (18%) were treated with behavioral modification alone (Behavior-only).
An episode-free period (EFP) ≥ 9 months was observed in 23 (82%) cats. Fifteen cats (94%) in the Fluoxetine-only group experienced an EFP of ≥ 9 months. Moreover, they had a shorter time to recovery (median [IQR] = 8 [3.5-18] days) compared to the Fluoxetine/Gabapentin + Behavior and Behavior-only groups (median [IQR] = 100 [90-210] and 60 [30-90] days, respectively). At the 1-year follow-up, 26 (93%) cats no longer had HS clinical signs and 14 (50%) were still under pharmacotherapy. Relapses were reported only in one case (4%).
Most of the cat's diagnosed with HS, and managed through various therapeutic strategies, experienced an EFP of more than 9 months and showed absence of clinical signs at 1 year follow-up.
感觉过敏综合征（HS）在猫中很常见，但人们对其了解甚少，推测其病因与神经和行为因素有关，且关于其预后和治疗的数据有限。
本研究旨在描述28只患有HS的猫通过各种治疗策略后的临床结局和治疗反应。
回顾了28只患有HS且至少随访1年的猫的临床记录。
对一组受HS影响的猫进行回顾性、观察性、描述性研究。16只猫（57%）仅接受氟西汀治疗（仅氟西汀组），7只（25%）采用行为矫正联合加巴喷丁或氟西汀治疗（氟西汀/加巴喷丁+行为组），5只（18%）仅采用行为矫正治疗（仅行为组）。
23只（82%）猫观察到无发作期（EFP）≥9个月。仅氟西汀组的15只猫（94%）经历了≥9个月的EFP。此外，与氟西汀/加巴喷丁+行为组和仅行为组相比，它们的恢复时间更短（中位数[四分位间距]=8[3.5-18]天），后两组的中位数[四分位间距]分别为100[90-210]天和60[30-90]天。在1年随访时，26只（93%）猫不再有HS临床症状，14只（50%）仍在接受药物治疗。仅1例（4%）报告有复发。
大多数被诊断为HS并通过各种治疗策略治疗的猫经历了超过9个月的EFP，且在1年随访时无临床症状。
