van Haaften Karen A, Forsythe Lauren R Eichstadt, Stelow Elizabeth A, Bain Melissa J
J Am Vet Med Assoc. 2017 Nov 15;251(10):1175-1181. doi: 10.2460/javma.251.10.1175.
OBJECTIVE To determine the effects of oral gabapentin administration prior to veterinary examination on signs of stress in cats. DESIGN Randomized, blinded, crossover clinical trial. ANIMALS 20 healthy pet cats with a history of fractious behavior or signs of stress during veterinary examination. PROCEDURES Cats were scheduled for 2 veterinary visits 1 week apart and randomly assigned to receive a capsule containing 100 mg of gabapentin (13.0 to 29.4 mg/kg [5.9 to 13.4 mg/lb]) or placebo (lactose powder) prior to the first visit and the opposite treatment prior to the second visit. Owners were instructed to administer the assigned capsule orally 90 minutes prior to placing the cat into a carrier and transporting it to the veterinary hospital. Standardized physical examinations and blood pressure readings were performed. Owners assigned a cat stress score during transportation and examination, and the veterinarian assigned a compliance score at the visit. Scores were compared between treatments, controlling for various factors. RESULTS Owner-assessed cat stress scores during transportation and veterinary examination and veterinarian-assessed compliance scores were significantly lower when cats received gabapentin than when they received the placebo. Sedation was a common effect of gabapentin administration, and ataxia, hypersalivation, and vomiting were also reported. All effects resolved within 8 hours after gabapentin administration. CONCLUSIONS AND CLINICAL RELEVANCE Owners' perception of stress in their cats is a primary reason for failing to seek veterinary care. Results of this study suggested that gabapentin is a safe and effective treatment for cats to help reduce stress and aggression and increase compliance for transportation and veterinary examination.
目的 确定在兽医检查前口服加巴喷丁对猫应激迹象的影响。 设计 随机、双盲、交叉临床试验。 动物 20 只健康宠物猫，有行为暴躁病史或在兽医检查时有应激迹象。 程序 安排猫进行两次间隔 1 周的兽医就诊，并随机分配在第一次就诊前接受一粒含 100 毫克加巴喷丁（13.0 至 29.4 毫克/千克[5.9 至 13.4 毫克/磅]）的胶囊或安慰剂（乳糖粉），在第二次就诊前接受相反的治疗。 主人被指示在将猫放入猫笼并送往兽医医院前 90 分钟口服指定的胶囊。 进行标准化体格检查和血压读数。 主人在运输和检查期间给猫评定应激评分，兽医在就诊时评定依从性评分。 比较不同治疗之间的评分，并控制各种因素。 结果 当猫接受加巴喷丁时，主人评定的运输和兽医检查期间的猫应激评分以及兽医评定的依从性评分显著低于接受安慰剂时。 镇静是加巴喷丁给药的常见效应，还报告了共济失调、流涎过多和呕吐。 所有效应在加巴喷丁给药后 8 小时内消失。 结论及临床意义 主人对其猫应激的认知是未能寻求兽医护理的主要原因。 本研究结果表明，加巴喷丁是一种安全有效的治疗方法，可帮助减轻猫的应激和攻击性，提高运输和兽医检查的依从性。
