Babizhaev M A, Deev A I, Nikolaev G M
Biofizika. 1985 Jul-Aug;30(4):671-4.
Water proton spin-spin relaxation times (T2) and the content of bound, "non-freezable" at -9 degrees C water in both normal human lenses and human lenses of different stages of cataract progression (cataracta incipiens, nondum matura, mature hypermatura) were measured by NMR spin echoes method. By the stage of cataracta nondum matura, increase of bound water content and simultaneous, almost half decrease of the relaxation time (T2), were observed. However, on the following stages of cataract evaluation (almost mature, mature cataracts) a gradual decrease of bound water content is noted, but only for the mature cataract stage the water content significantly differs from that of the normal one. On the stage of hypermature cataract the presence of two unexchanged with each other fractions of water is found. The obtained data are explained by lens protein reconstructions during the cataract progression.
采用核磁共振自旋回波法测量了正常人晶状体以及不同白内障进展阶段（初期白内障、未成熟白内障、成熟白内障、过熟白内障）的人晶状体中水质子自旋 - 自旋弛豫时间（T2）以及在 -9℃下结合的“不可冻结”水的含量。在未成熟白内障阶段，观察到结合水含量增加，同时弛豫时间（T2）几乎减半。然而，在白内障评估的后续阶段（几乎成熟、成熟白内障），结合水含量逐渐降低，但仅在成熟白内障阶段，其水含量与正常晶状体的水含量有显著差异。在过熟白内障阶段，发现存在两个彼此未交换的水组分。所获得的数据通过白内障进展过程中晶状体蛋白的重构来解释。
