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生物制剂改变了重度T2高哮喘患者呼出气一氧化氮分数与痰液嗜酸性粒细胞之间的关系。

Biologics alter the relationship between exhaled nitric oxide fraction and sputum eosinophils in severe T2-high asthma patients.

作者信息

Sabbe Mare, Schleich Florence, Louis Renaud

机构信息

CHU de Liege, Service de Pneumologie, Liege, Belgium.

出版信息

ERJ Open Res. 2025 Jun 16;11(3). doi: 10.1183/23120541.00783-2024. eCollection 2025 May.

DOI:10.1183/23120541.00783-2024
PMID:40524926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12168171/
Abstract

https://bit.ly/49mPQC5.

摘要

https://bit.ly/49mPQC5.（此为网址，一般保留原文不翻译）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ce9/12168171/799149691c99/00783-2024.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ce9/12168171/799149691c99/00783-2024.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ce9/12168171/799149691c99/00783-2024.01.jpg

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Biologics alter the relationship between exhaled nitric oxide fraction and sputum eosinophils in severe T2-high asthma patients.生物制剂改变了重度T2高哮喘患者呼出气一氧化氮分数与痰液嗜酸性粒细胞之间的关系。
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本文引用的文献

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When sequential use of mepolizumab and dupilumab in a severe atopic eosinophilic asthmatic questions the role of eosinophils in mediating the clinical expression of the disease: a case report.美泊利珠单抗和度匹鲁单抗序贯治疗重度特应性嗜酸性粒细胞性哮喘质疑嗜酸性粒细胞在介导疾病临床表型中的作用：病例报告。
J Med Case Rep. 2024 Jan 31;18(1):63. doi: 10.1186/s13256-023-04255-8.
2
Sputum cytokines associated with raised FeNO after anti-IL5 biologic therapy in severe asthma.在重度哮喘患者接受抗白细胞介素-5生物治疗后，与呼出一氧化氮（FeNO）升高相关的痰液细胞因子
Allergy. 2024 Aug;79(8):2244-2247. doi: 10.1111/all.16011. Epub 2024 Jan 10.
3
Benralizumab in severe eosinophilic asthma in real life: confirmed effectiveness and contrasted effect on sputum eosinophilia exhaled nitric oxide fraction - PROMISE.
倍利珠单抗在重度嗜酸性粒细胞性哮喘真实世界中的应用：已证实的有效性及对痰液嗜酸性粒细胞、呼出一氧化氮分数的对比影响——PROMISE研究
ERJ Open Res. 2023 Nov 27;9(6). doi: 10.1183/23120541.00383-2023. eCollection 2023 Nov.
4
Benralizumab Normalizes Sputum Eosinophilia in Severe Asthma Uncontrolled by Anti-IL-5 Antibodies: A Single-Blind, Placebo-controlled Clinical Trial.贝那利珠单抗可使抗IL-5抗体治疗无法控制的重度哮喘患者痰液嗜酸性粒细胞水平恢复正常：一项单盲、安慰剂对照临床试验。
Am J Respir Crit Care Med. 2023 Dec 15;208(12):1330-1335. doi: 10.1164/rccm.202308-1413LE.
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Effect of dupilumab on sputum eosinophils in patients with moderate-to-severe asthma.度普利尤单抗对中重度哮喘患者痰液嗜酸性粒细胞的影响。
Allergy. 2024 Feb;79(2):509-513. doi: 10.1111/all.15901. Epub 2023 Sep 26.
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Sub-stratification of type-2 high airway disease for therapeutic decision-making: A 'bomb' (blood eosinophils) meets 'magnet' (FeNO) framework.用于治疗决策的2型高气道疾病亚分层：“炸弹”（血液嗜酸性粒细胞）与“磁铁”（呼出一氧化氮）框架。
Respirology. 2022 Aug;27(8):573-577. doi: 10.1111/resp.14294. Epub 2022 May 19.
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Are type-2 biomarkers of any help in asthma diagnosis?2型生物标志物对哮喘诊断有帮助吗？
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