Quach Duyen, Nguyen Kayla, Tavera Gabriella, Wright Rachel, Ali Zuhair, Liang Mike
Department of Surgery, Graduate Medical Education, HCA Healthcare, Kingwood, TX, United States of America.
Tilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX, United States of America.
Surg Open Sci. 2025 Jun 3;26:128-134. doi: 10.1016/j.sopen.2025.06.001. eCollection 2025 Jun.
Biliary dyskinesia is disorder characterized by reduced gallbladder ejection fraction, which have shown a good response to cholecystectomy. In contrast, hyperkinetic biliary dyskinesia (HBD), as defined by ejection fraction ≥80 %, is an emerging phenomenon, and the role of cholecystectomy is not yet clearly defined. This review investigates the effectiveness of cholecystectomy in alleviating symptoms of HBD.
A comprehensive literature search was conducted to retrieve studies based on predefined inclusion criteria. Data were extracted by two-independent reviewers. A random-effects model was used for meta-analysis. Risk ratios (RR) were calculated to estimate the impact of cholecystectomy on symptom improvement. Heterogeneity was calculated using the I statistic and Q-test, with subgroup analyses performed based on study design.
Fourteen studies involving 416 patients with HBD were included. Overall, the pooled RR for symptom relief post-cholecystectomy was 3.72 (95 % CI: 2.57-5.38). A subgroup analysis of retrospective reviews showed an RR of 3.9 (95 % CI: 2.57-5.92). Moderate heterogeneity (I = 30.01 %) was observed.
Based on existing evidence, cholecystectomy appeared to be a promising and effective treatment for HBD in select patients.
胆囊运动功能障碍是一种以胆囊排空分数降低为特征的疾病，已显示出对胆囊切除术有良好反应。相比之下，以排空分数≥80%定义的运动亢进性胆囊运动功能障碍（HBD）是一种新出现的现象，胆囊切除术的作用尚未明确界定。本综述研究了胆囊切除术缓解HBD症状的有效性。
进行全面的文献检索，以检索基于预定义纳入标准的研究。由两名独立的审阅者提取数据。采用随机效应模型进行荟萃分析。计算风险比（RR）以估计胆囊切除术对症状改善的影响。使用I统计量和Q检验计算异质性，并根据研究设计进行亚组分析。
纳入了14项涉及416例HBD患者的研究。总体而言，胆囊切除术后症状缓解的合并RR为3.72（95%CI：2.57 - 5.38）。回顾性综述的亚组分析显示RR为3.9（95%CI：2.57 - 5.92）。观察到中度异质性（I = 30.01%）。
基于现有证据，胆囊切除术似乎是治疗特定患者HBD的一种有前景且有效的方法。
