Role of cholecystectomy in hyperkinetic biliary dyskinesia: A systematic review and meta-analysis.

BACKGROUND

Biliary dyskinesia is disorder characterized by reduced gallbladder ejection fraction, which have shown a good response to cholecystectomy. In contrast, hyperkinetic biliary dyskinesia (HBD), as defined by ejection fraction ≥80 %, is an emerging phenomenon, and the role of cholecystectomy is not yet clearly defined. This review investigates the effectiveness of cholecystectomy in alleviating symptoms of HBD.

MATERIAL AND METHODS

A comprehensive literature search was conducted to retrieve studies based on predefined inclusion criteria. Data were extracted by two-independent reviewers. A random-effects model was used for meta-analysis. Risk ratios (RR) were calculated to estimate the impact of cholecystectomy on symptom improvement. Heterogeneity was calculated using the I statistic and Q-test, with subgroup analyses performed based on study design.

RESULTS

Fourteen studies involving 416 patients with HBD were included. Overall, the pooled RR for symptom relief post-cholecystectomy was 3.72 (95 % CI: 2.57-5.38). A subgroup analysis of retrospective reviews showed an RR of 3.9 (95 % CI: 2.57-5.92). Moderate heterogeneity (I = 30.01 %) was observed.

CONCLUSION

Based on existing evidence, cholecystectomy appeared to be a promising and effective treatment for HBD in select patients.