具有聚（酰胺 - 胺）链段的氯磺化聚乙烯制成的肝素化接枝共聚物。

Heparinizable graft copolymers from chlorosulphonated polyethylene with poly(amido-amine) segments.

作者信息

Tanzi M C, Barozzi C, Tieghi G, Ferrara R, Casini G, Tempesti F

出版信息

Biomaterials. 1985 Jul;6(4):273-6. doi: 10.1016/0142-9612(85)90025-0.

Abstract

The synthesis and the physical characterization of three graft copolymers (PES/PAA) obtained from chlorosulphonated polyethylene (PECS) and three different secondary amino end-capped poly(amido-amine)s are reported. The properties of these heparinizable materials appear to be suitable for constructing prosthetic devices for biomedical use. The heparin adsorbing ability and the stability of the complex with heparin of the three copolymers have been evaluated, by means of biological tests, as activated Partial Thromboplastin Time (PTT) and Thrombin Time (TT).

摘要

报道了由氯磺化聚乙烯（PECS）和三种不同的仲氨基封端的聚（酰胺-胺）制备的三种接枝共聚物（PES/PAA）的合成及物理表征。这些可肝素化材料的性能似乎适合用于构建生物医学用的假体装置。通过活化部分凝血活酶时间（PTT）和凝血酶时间（TT）等生物学测试，评估了三种共聚物的肝素吸附能力及其与肝素复合物的稳定性。