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可肝素化材料(III)。聚(酰胺 - 胺)作为交联树脂或表面接枝在聚氯乙烯上时的肝素保留能力。

Heparinizable materials (III). Heparin retention power of a poly(amido-amine) either as crosslinked resin, or surface-grafted on PVC.

作者信息

Ferruti P, Casini G, Tempesti F, Barbucci R, Mastacchi R, Sarret M

出版信息

Biomaterials. 1984 Jul;5(4):234-6. doi: 10.1016/0142-9612(84)90021-8.

Abstract

The retentive power of a poly(amido-amine), in the form of a highly hydrophilic crosslinked resin, has been evaluated at different pH's. The resin releases heparin quantitatively in a very narrow pH range (10.8-11.4). This poly(amido-amine) has also been grafted on PVC tubes, and the heparin-adsorbing capacity of the materials so obtained has been tested biologically. In this case heparin is only released at pH greater than 10 so confirming the strong interaction between our polymer and heparin.

摘要

一种呈高度亲水性交联树脂形式的聚(酰胺 - 胺)的保留能力已在不同pH值下进行了评估。该树脂在非常窄的pH范围(10.8 - 11.4)内定量释放肝素。这种聚(酰胺 - 胺)也已接枝到聚氯乙烯管上,并且对如此获得的材料的肝素吸附能力进行了生物学测试。在这种情况下,肝素仅在pH大于10时释放,从而证实了我们的聚合物与肝素之间的强相互作用。

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