Setty B S, Riar S S, Kar A B
Fertil Steril. 1977 Jun;28(6):674-81. doi: 10.1016/s0015-0282(16)42623-3.
The effects of castration and testosterone replacement therapy on the histology and biochemical composition (RNA, DNA, total protein, alkaline phosphatase, acid phosphatase, hyaluronidase, sialic acid, glycogen, phospholipids, and glycerylphosphorylcholine [GPC]) of the epididymis of the rabbit and rhesus monkey were investigated. Castration produced marked ponderal, histologic, and biochemical changes in the epididymis. In the androgen-deficient state the tubular diameter and epithelial cell height were reduced and there was an increase in interbular stroma. The levels of RNA, DNA, phospholipids, and GPC were also reduced in castrated animals. Testosterone treatment restored the histologic features and the levels of various biochemical constituents to a great extent but not to the intact control level. The importance of endocrine and exocrine factors of the testis in relation to epididymal function is discussed.
研究了去势及睾酮替代疗法对兔和恒河猴附睾组织学及生化成分（RNA、DNA、总蛋白、碱性磷酸酶、酸性磷酸酶、透明质酸酶、唾液酸、糖原、磷脂和甘油磷酸胆碱[GPC]）的影响。去势导致附睾出现明显的重量、组织学和生化变化。在雄激素缺乏状态下，管腔直径和上皮细胞高度减小，管间基质增加。去势动物的RNA、DNA、磷脂和GPC水平也降低。睾酮治疗在很大程度上恢复了组织学特征和各种生化成分的水平，但未恢复到完整对照水平。讨论了睾丸内分泌和外分泌因素与附睾功能的关系。
