• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于水两亲性三元共聚物的生物相容性、无眩光且可折叠人工晶状体的战略设计

Strategic Design of Biocompatible, Glistening-Free, and Foldable Artificial Intraocular Lenses Based on Hydro-Amphiphilic Ternary Copolymers.

作者信息

Hu Cheng-Ti, Liang Zhi-Xuan, Luo Jhen-Yu, Chiu Po-Hsun, Day Annabelle I, Hsieh Chih-Chen, Shih Po-Jen, Li Jia-Han, Kuo Bo-I, Wang I-Jong, Yen Jia-Yush, Dai Chi-An

机构信息

Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.

Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan.

出版信息

Biomacromolecules. 2025 Jul 14;26(7):4612-4625. doi: 10.1021/acs.biomac.5c00588. Epub 2025 Jun 17.

DOI:10.1021/acs.biomac.5c00588
PMID:40526039
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12264951/
Abstract

The increasing prevalence of cataracts underscores the urgent need for intraocular lens (IOL) materials that provide optical clarity, foldability, glistening resistance, and long-term biocompatibility. In this study, we developed hydro-amphiphilic ternary copolymers composed of styrene, hydroxyethyl methacrylate (HEMA), and poly(ethylene glycol) phenyl ether acrylate (PEGPEA) to address these requirements. This rational design integrates the strength and refractive index of hydrophobic styrene with the flexibility and hydrophilicity of HEMA and PEGPEA. The optimized formulation (H3), comprising 50 wt % HEMA, 30 wt % PEGPEA, and 20 wt % styrene, showed excellent transparency after accelerated aging, sufficient modulus and elongation for safe surgical handling, and low cytotoxicity in CCK-8 assays. Cytokine analyses revealed no significant inflammatory response compared to a commercial hydrophobic acrylic IOL. These findings highlight hydro-amphiphilic copolymers as a promising next-generation material platform for IOLs, offering a biocompatible, glistening-free, and foldable solution for enhanced surgical outcomes and long-term patient satisfaction.

摘要

白内障患病率的不断上升突显了对眼内晶状体（IOL）材料的迫切需求，这些材料需具备光学清晰度、可折叠性、抗闪烁性和长期生物相容性。在本研究中，我们开发了由苯乙烯、甲基丙烯酸羟乙酯（HEMA）和聚（乙二醇）苯醚丙烯酸酯（PEGPEA）组成的亲水-疏水三元共聚物，以满足这些要求。这种合理的设计将疏水苯乙烯的强度和折射率与HEMA和PEGPEA的柔韧性和亲水性相结合。优化配方（H3）包含50 wt%的HEMA、30 wt%的PEGPEA和20 wt%的苯乙烯，在加速老化后显示出优异的透明度，具有足够的模量和伸长率以确保安全的手术操作，并且在CCK-8试验中具有低细胞毒性。细胞因子分析显示，与市售疏水丙烯酸IOL相比，没有明显的炎症反应。这些发现突出了亲水-疏水共聚物作为IOL有前景的下一代材料平台，为提高手术效果和患者长期满意度提供了一种生物相容、无闪烁且可折叠的解决方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/fb23d6580242/bm5c00588_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/2e32f243d18f/bm5c00588_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/93b8ce100299/bm5c00588_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/772633e2ec3c/bm5c00588_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/cff54b822b99/bm5c00588_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/57f7ff3379db/bm5c00588_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/680e25f29ffc/bm5c00588_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/9765175d730b/bm5c00588_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/98b8dcb19fc9/bm5c00588_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/6ad33ae4a8dc/bm5c00588_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/3a74f0765ee1/bm5c00588_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/fb23d6580242/bm5c00588_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/2e32f243d18f/bm5c00588_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/93b8ce100299/bm5c00588_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/772633e2ec3c/bm5c00588_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/cff54b822b99/bm5c00588_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/57f7ff3379db/bm5c00588_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/680e25f29ffc/bm5c00588_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/9765175d730b/bm5c00588_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/98b8dcb19fc9/bm5c00588_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/6ad33ae4a8dc/bm5c00588_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/3a74f0765ee1/bm5c00588_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f501/12264951/fb23d6580242/bm5c00588_0010.jpg

相似文献

1
Strategic Design of Biocompatible, Glistening-Free, and Foldable Artificial Intraocular Lenses Based on Hydro-Amphiphilic Ternary Copolymers.基于水两亲性三元共聚物的生物相容性、无眩光且可折叠人工晶状体的战略设计
Biomacromolecules. 2025 Jul 14;26(7):4612-4625. doi: 10.1021/acs.biomac.5c00588. Epub 2025 Jun 17.
2
Fine-tuning equilibrium water content and mechanical properties of acrylic-based copolymers for intraocular lens applications.用于眼内晶状体应用的丙烯酸基共聚物的平衡含水量和机械性能的微调
Biomed Mater. 2025 Jul 9;20(4). doi: 10.1088/1748-605X/ade8c7.
3
One-year outcomes of a trifocal intraocular lens with glistening-free hydrophobic acrylic using the mix-and-match technique.采用混合匹配技术的无闪光疏水丙烯酸三焦点人工晶状体的一年期结果。
BMC Ophthalmol. 2025 Jul 1;25(1):370. doi: 10.1186/s12886-025-04198-2.
4
Intraocular lens optic edge design for the prevention of posterior capsule opacification after cataract surgery.白内障手术后预防后囊膜混浊的人工晶状体光学边缘设计。
Cochrane Database Syst Rev. 2021 Aug 16;8(8):CD012516. doi: 10.1002/14651858.CD012516.pub2.
5
Trifocal versus extended depth of focus (EDOF) intraocular lenses after cataract extraction.白内障摘除术后三焦点与扩展景深（EDOF）人工晶状体的比较。
Cochrane Database Syst Rev. 2024 Jul 10;7(7):CD014891. doi: 10.1002/14651858.CD014891.pub2.
6
Trifocal intraocular lenses versus bifocal intraocular lenses after cataract extraction among participants with presbyopia.多焦点人工晶状体与白内障摘除术后老视患者的双焦点人工晶状体比较。
Cochrane Database Syst Rev. 2023 Jan 27;1(1):CD012648. doi: 10.1002/14651858.CD012648.pub3.
7
Blue-light filtering intraocular lenses (IOLs) for protecting macular health.用于保护黄斑健康的蓝光滤过型人工晶状体
Cochrane Database Syst Rev. 2018 May 22;5(5):CD011977. doi: 10.1002/14651858.CD011977.pub2.
8
Multifocal versus monofocal intraocular lenses after cataract extraction.白内障摘除术后多焦点与单焦点人工晶状体的比较
Cochrane Database Syst Rev. 2016 Dec 12;12(12):CD003169. doi: 10.1002/14651858.CD003169.pub4.
9
[Osmogenic causes of reversible changes in light scattering power and refraction of hydrophilic intraocular lens in the early postoperative period].[术后早期亲水性人工晶状体光散射能力和屈光可逆性变化的渗透成因]
Vestn Oftalmol. 2025;141(3):27-36. doi: 10.17116/oftalma202514103127.
10
Surgical interventions for bilateral congenital cataract in children aged two years and under.儿童两岁及以下双侧先天性白内障的手术干预。
Cochrane Database Syst Rev. 2022 Sep 15;9(9):CD003171. doi: 10.1002/14651858.CD003171.pub3.

本文引用的文献

1
Application of Silicone in Ophthalmology: A Review.硅酮在眼科中的应用：综述
Materials (Basel). 2024 Jul 12;17(14):3454. doi: 10.3390/ma17143454.
2
Laser-assisted cataract surgery versus standard ultrasound phacoemulsification cataract surgery.激光辅助白内障手术与标准超声乳化白内障手术的比较。
Cochrane Database Syst Rev. 2023 Jun 23;6(6):CD010735. doi: 10.1002/14651858.CD010735.pub3.
3
Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices-A Systematic Review.
正电子湮没寿命谱作为药物辅料、药物递送系统和医疗器械固态表征的特殊技术——系统综述
Pharmaceuticals (Basel). 2023 Feb 7;16(2):252. doi: 10.3390/ph16020252.
4
Efficiency of a polymer-coated phacoemulsification tip in cataract surgery.聚合物涂层超声乳化针头在白内障手术中的效率
J Cataract Refract Surg. 2023 Oct 1;49(10):1056-1060. doi: 10.1097/j.jcrs.0000000000001198.
5
Current State of the Art and Next Generation of Materials for a Customized IntraOcular Lens according to a Patient-Specific Eye Power.根据患者特定眼屈光度定制人工晶状体的当前技术水平及下一代材料
Polymers (Basel). 2023 Mar 22;15(6):1590. doi: 10.3390/polym15061590.
6
Cataracts.白内障。
Lancet. 2023 Feb 4;401(10374):377-389. doi: 10.1016/S0140-6736(22)01839-6. Epub 2022 Dec 21.
7
Recent Advances of Intraocular Lens Materials and Surface Modification in Cataract Surgery.白内障手术中人工晶状体材料及表面改性的最新进展
Front Bioeng Biotechnol. 2022 Jun 8;10:913383. doi: 10.3389/fbioe.2022.913383. eCollection 2022.
8
Water-Induced Crystal Transition and Accelerated Relaxation Process of Polyamide 4 Chains in Microfibers.水诱导的聚酰胺 4 链在微纤维中的晶体转变和松弛过程加速。
Biomacromolecules. 2022 Aug 8;23(8):3458-3468. doi: 10.1021/acs.biomac.2c00618. Epub 2022 Jun 24.
9
Foldable Bulk Anti-adhesive Polyacrylic Intraocular Lens Material Design and Fabrication for Posterior Capsule Opacification Prevention.可折叠大容量抗粘连聚甲基丙烯酸甲酯眼内透镜材料设计与制作用于预防后囊混浊。
Biomacromolecules. 2022 Apr 11;23(4):1581-1591. doi: 10.1021/acs.biomac.1c01388. Epub 2022 Mar 10.
10
Posterior Capsule Opacification after Cataract Surgery via Implantation with Hydrophobic Acrylic Lens Compared with Silicone Intraocular Lens: A Systematic Review and Meta-Analysis.与硅酮人工晶状体相比，植入疏水丙烯酸晶状体的白内障手术后后囊膜混浊：一项系统评价和荟萃分析
J Ophthalmol. 2022 Feb 25;2022:3570399. doi: 10.1155/2022/3570399. eCollection 2022.