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根据患者特定眼屈光度定制人工晶状体的当前技术水平及下一代材料

Current State of the Art and Next Generation of Materials for a Customized IntraOcular Lens according to a Patient-Specific Eye Power.

作者信息

Vacalebre Martina, Frison Renato, Corsaro Carmelo, Neri Fortunato, Santoro Antonio, Conoci Sabrina, Anastasi Elena, Curatolo Maria Cristina, Fazio Enza

机构信息

Dipartimento di Scienze Matematiche ed Informatiche, Scienze Fisiche e Scienze della Terra (MIFT), Università di Messina, V.le Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

Optical Consultant SIFI SpA, 95025 Aci Sant'Antonio (CT), Italy.

出版信息

Polymers (Basel). 2023 Mar 22;15(6):1590. doi: 10.3390/polym15061590.

DOI:10.3390/polym15061590
PMID:36987370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10054364/
Abstract

Intraocular lenses (IOLs) are commonly implanted after surgical removal of a cataractous lens. A variety of IOL materials are currently available, including collamer, hydrophobic acrylic, hydrophilic acrylic, PHEMA copolymer, polymethylmethacrylate (PMMA), and silicone. High-quality polymers with distinct physical and optical properties for IOL manufacturing and in line with the highest quality standards on the market have evolved to encompass medical needs. Each of them and their packaging show unique advantages and disadvantages. Here, we highlight the evolution of polymeric materials and mainly the current state of the art of the unique properties of some polymeric systems used for IOL design, identifying current limitations for future improvements. We investigate the characteristics of the next generation of IOL materials, which must satisfy biocompatibility requirements and have tuneable refractive index to create patient-specific eye power, preventing formation of posterior capsular opacification.

摘要

人工晶状体（IOL）通常在手术摘除白内障晶状体后植入。目前有多种IOL材料可供选择，包括可折叠人工晶状体、疏水丙烯酸酯、亲水丙烯酸酯、聚甲基丙烯酸羟乙酯共聚物、聚甲基丙烯酸甲酯（PMMA）和硅酮。已开发出具有独特物理和光学特性、符合市场最高质量标准的高质量聚合物，以满足医疗需求。它们中的每一种及其包装都有独特的优缺点。在此，我们重点介绍聚合材料的发展历程，主要是用于IOL设计的一些聚合系统的独特性能的当前技术水平，确定当前的局限性以便未来改进。我们研究下一代IOL材料的特性，这些材料必须满足生物相容性要求，并具有可调节的折射率以产生针对患者的眼屈光度，防止后囊膜混浊的形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/2e00cd171a13/polymers-15-01590-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/52a137f32f91/polymers-15-01590-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/827a5e2ea1e0/polymers-15-01590-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/df9f118699ec/polymers-15-01590-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/f729d7d07e6a/polymers-15-01590-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/e13510259384/polymers-15-01590-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/3574b11f646c/polymers-15-01590-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/c517e2b56996/polymers-15-01590-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/c8de8a940622/polymers-15-01590-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/09e2db14e354/polymers-15-01590-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/7e65e0eb8d57/polymers-15-01590-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/6b36aef7f7af/polymers-15-01590-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/2e00cd171a13/polymers-15-01590-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/52a137f32f91/polymers-15-01590-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/827a5e2ea1e0/polymers-15-01590-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/df9f118699ec/polymers-15-01590-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/f729d7d07e6a/polymers-15-01590-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/e13510259384/polymers-15-01590-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/3574b11f646c/polymers-15-01590-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/c517e2b56996/polymers-15-01590-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/c8de8a940622/polymers-15-01590-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/09e2db14e354/polymers-15-01590-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/7e65e0eb8d57/polymers-15-01590-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/6b36aef7f7af/polymers-15-01590-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3fa/10054364/2e00cd171a13/polymers-15-01590-g012.jpg

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4
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