Fernández-Castro Mónica, Plaza-Almuedo Zulema, Rosas Jose, Martínez-Taboada Victor, Olivé Alejandro, Menor-Almagro Raúl, Serrano-Benavente Belen, Font-Urgelles Judit, García-Aparicio Angel, Manrique-Arija Sara, García-Vadillo Jesus Alberto, López-González Ruth, Narváez Javier, Rodriguez-Lozano Beatriz, Galisteo Carlos, González-Martín Jorge, Vela-Casasempere Paloma, Bohórquez Cristina, Erausquin Celia, Paredes-Romero Beatriz, Riancho-Zarrabeitia Leyre, Melchor-Diaz Sheila, Pego-Reigosa Jose Maria, Heredia Sergi, Moriano Clara, Blazquez-Cañamero Maria Angeles, Estrada Paula, Júdez Enrique, Belzunegui Joaquín María, Ramos Consuelo, Sánchez-Alonso Fernando, Andreu Jose Luis
Rheumatology department, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain.
Research Unit, Spanish Society of Rheumatology, Madrid, Spain.
Rheumatol Int. 2025 Jun 17;45(7):156. doi: 10.1007/s00296-025-05909-0.
The objective of SjögrenSER Prospective (SjD-PROS) was to evaluate the improvement, stability or progression of SjD in clinical practice. SjD-PROS is an observational, longitudinal, multicenter study of SjD in Spain. Participants from the prior transversal phase were invited to a follow-up visit after 9.5 years. Data were collected via interviews and medical records. Variables were analyzed using means, medians and frequencies. Statistical associations were assessed using T student test, Kruskal-Wallis and the Chi-square test. We included 314 patients, 95% women (mean age of 66 years; mean disease duration of 17 years). At follow-up visit, the most frequent systemic manifestations were arthralgias (54%) and hematological involvement (49%), with arthralgias being significantly less frequent than at baseline visit (p < 0.001); the most affected organs were the lung (15.6%) and the kidney (11.5%). Half of the patients in SjD-PROS, had positive rheumatoid factor, 16% less than at baseline visit; β2-microglobulin was significantly elevated compared to baseline visit (62.5%, p < 0.001). Articular, pulmonary, hematological and biological domains of ESSDAI index showed the greatest changes, both in improvement and worsening, and the greatest activity. Systemic treatments use was significantly higher in patients showing activity in ESSDAI. This study offers valuable insights into the most variable clinical and serological manifestations throughout the course of SjD. ESSDAI domains showing the greatest changes reflected the greatest treatments needs. These findings allow for patient stratification based on phenotype, a crucial step in designing follow-up protocols.
干燥综合征前瞻性研究（SjögrenSER Prospective，SjD-PROS）的目的是评估临床实践中干燥综合征（SjD）的改善、稳定或进展情况。SjD-PROS是一项在西班牙进行的关于SjD的观察性、纵向、多中心研究。来自先前横断面阶段的参与者在9.5年后被邀请进行随访。数据通过访谈和医疗记录收集。使用均值、中位数和频率对变量进行分析。使用t检验、Kruskal-Wallis检验和卡方检验评估统计关联。我们纳入了314例患者，其中95%为女性（平均年龄66岁；平均病程17年）。在随访时，最常见的全身表现是关节痛（54%）和血液系统受累（49%），关节痛的发生率显著低于基线访视时（p<0.001）；受影响最严重的器官是肺（15.6%）和肾（11.5%）。SjD-PROS中一半的患者类风湿因子呈阳性，比基线访视时减少了16%；与基线访视相比，β2微球蛋白显著升高（62.5%，p<0.001）。ESSDAI指数的关节、肺部、血液学和生物学领域在改善和恶化方面变化最大，且活动度最高。在ESSDAI中有活动表现的患者全身治疗的使用率显著更高。这项研究为SjD病程中最具变异性的临床和血清学表现提供了有价值的见解。变化最大的ESSDAI领域反映了最大的治疗需求。这些发现有助于根据表型对患者进行分层，这是设计随访方案的关键步骤。
