Huang Y H, Maas J W, Hu G H
Eur J Pharmacol. 1980 Nov 7;68(1):41-7. doi: 10.1016/0014-2999(80)90058-8.
The firing of hippocampal cells was studied in rats treated with desipramine 10 mg/kg per day i.p. for various periods of time. These cells were neurophysiologically identified to be noradrenergic postsynaptic by their decreased firing during stimulation of the locus coeruleus (LC). While desipramine given for 1 day produced no change, the drug given for 7, 14, and 21 days produced a 20%, 38% and 89% increase, respectively; only the last increase reached a statistical significance. This time course closely resembles that of the therapeutic action of the drug in depressed patients. Desipramine also altered the firing of norepinephrine-containing cells in the LC. While desipramine given for 1 day produced no change, the drug given for 7, 14 and 21 days produced a 12%, 29% and 34% decrease, respectively; only the last two decrements reached a statistical significance. This time course resembles that of the change in firing of hippocampal cells. Based on this and other data it is suggested that the decrease in the firing of LC cells plays a major role in the increased firing of hippocampal cells obtained after desipramine treatment.
研究了每天腹腔注射10mg/kg去甲丙咪嗪，持续不同时间的大鼠海马细胞的放电情况。通过在刺激蓝斑（LC）期间它们放电减少，这些细胞在神经生理学上被鉴定为去甲肾上腺素能突触后细胞。虽然注射1天的去甲丙咪嗪没有产生变化，但注射7天、14天和21天的药物分别使放电增加了20%、38%和89%；只有最后一次增加达到统计学显著水平。这个时间进程与该药物在抑郁症患者中的治疗作用的时间进程非常相似。去甲丙咪嗪也改变了LC中含去甲肾上腺素细胞的放电。虽然注射1天的去甲丙咪嗪没有产生变化，但注射7天、14天和21天的药物分别使放电减少了12%、29%和34%；只有最后两次减少达到统计学显著水平。这个时间进程与海马细胞放电变化的时间进程相似。基于此及其他数据，提示LC细胞放电减少在去甲丙咪嗪治疗后海马细胞放电增加中起主要作用。
