Birnstiel S, Haas H L
Physiologisches Institut, Johannes-Gutenberg-Universität, Mainz, Federal Republic of Germany.
Naunyn Schmiedebergs Arch Pharmacol. 1991 Jul;344(1):79-83. doi: 10.1007/BF00167385.
The actions of three clinically effective antidepressant drugs with different pharmacological profiles were investigated in the CA1 area of rat hippocampal slices. Imipramine and (+) or (-)-oxaprotiline had negligible effects on population spikes evoked by stratum radiatum stimulation, but reduced postsynaptic excitability in low Ca high Mg medium after an exposure of more than 15 min. Imipramine and (+)-oxaprotiline at 10 mumol/l enhanced long-term potentiation (LTP) when a lower stimulation strength was applied while (+)-oxaprotiline reduced LTP when a higher stimulus amplitude was used to evoke population spikes. (-)-oxaprotiline (levoprotiline) had a similar effect which was, however, not significant in either stimulation paradigm at the P less than 0.05 level. Imipramine actions were also studied on epileptiform discharges in Mg(2+)-free medium: a facilitation-inhibition sequence with a slow time course was seen with 50 mumol/l but no effect with 10 mumol/l. An involvement of N-methyl-D-aspartate (NMDA)-receptors in acute actions of antidepressants is unlikely but long-term potentiation in the hippocampus is modulated by these drugs.
研究了三种具有不同药理学特性的临床有效抗抑郁药物在大鼠海马切片CA1区的作用。丙咪嗪和（+）或（-）-奥沙普替林对辐射层刺激诱发的群体峰电位影响可忽略不计，但在低钙高镁培养基中暴露超过15分钟后，可降低突触后兴奋性。当施加较低刺激强度时，10 μmol/L的丙咪嗪和（+）-奥沙普替林增强长时程增强（LTP），而当使用较高刺激幅度诱发群体峰电位时，（+）-奥沙普替林降低LTP。（-）-奥沙普替林（左洛普替林）有类似作用，然而，在两种刺激模式下，在P<0.05水平均无显著意义。还研究了丙咪嗪在无镁培养基中对癫痫样放电的作用：50 μmol/L时可见缓慢时程的促进-抑制序列，而10 μmol/L时无作用。抗抑郁药的急性作用不太可能涉及N-甲基-D-天冬氨酸（NMDA）受体，但这些药物可调节海马中的长时程增强。
