一例因摄入亚氯酸钠导致的高铁血红蛋白血症和溶血病例。
A Case of Methemoglobinemia and Hemolysis from Sodium Chlorite Ingestion.
作者信息
Liu Jessica, Patel Matthew, Vigna Marisa, Hewitt Mark Keith, Lim Wendy
机构信息
Department of Medicine, Western University, London, ON, Canada.
Department of Medicine, University of Toronto, Toronto, ON, Canada.
出版信息
Clin Med Res. 2025 Mar;23(1):21-25. doi: 10.3121/cmr.2025.1954.
Sodium chlorite is a household and industrial cleaning agent that can cause oxidative stress leading to methemoglobinemia and severe hemolysis when ingested. There is a scarcity of published literature reporting this in humans. We report a case of intentional sodium chlorite ingestion for homeopathic purposes that resulted in methemoglobinemia and hemolysis, requiring admission to the intensive care unit. Following successful treatment with methylene blue, the patient developed worsening hemolytic activity. Outpatient testing later revealed she was non- glucose-6-phosphate dehydrogenase (G6PD) deficient. Hemolysis precipitated by methylene blue is an underrecognized side effect that can be observed in individuals both with and without G6PD deficiency.
亚氯酸钠是一种家用和工业清洁剂，摄入后可导致氧化应激，进而引发高铁血红蛋白血症和严重溶血。关于人类发生这种情况的已发表文献很少。我们报告了一例因顺势疗法目的故意摄入亚氯酸钠导致高铁血红蛋白血症和溶血的病例，患者需要入住重症监护病房。在用亚甲蓝成功治疗后，患者的溶血活性恶化。门诊检查后来发现她缺乏葡萄糖-6-磷酸脱氢酶（G6PD）。亚甲蓝引发的溶血是一种未得到充分认识的副作用，在有或没有G6PD缺乏的个体中都可能观察到。
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