去甲肾上腺素能蓝斑系统损伤大鼠的惊厥性和非惊厥性乙醇戒断行为

Convulsive and non-convulsive ethanol withdrawal behaviour in rats with lesions of the noradrenergic locus coeruleus system.

作者信息

Clemmesen L, Lindvall O, Hemmingsen R, Ingvar M, Bolwig T G

出版信息

Brain Res. 1985 Oct 28;346(1):164-7. doi: 10.1016/0006-8993(85)91109-6.

Abstract

The ascending noradrenergic pathways from the locus coeruleus were lesioned bilaterally in 10 rats by intracerebral 6-hydroxydopamine injections. Ten rats were sham-operated. All animals were subjected to a 4-day ethanol intoxication period using intragastric intubation. Intoxication and withdrawal assessments were performed blindly. The 6-hydroxydopamine lesions did not appear to affect tolerance to ethanol. During withdrawal, however, lesioned animals showed minor, but statistically significant changes in scores of certain non-convulsive withdrawal signs, but incidence and intensity of spontaneous and audiogenic convulsive seizures were not different between the groups.

摘要

通过脑室内注射6-羟基多巴胺，对10只大鼠双侧蓝斑的去甲肾上腺素能上行通路进行损伤。10只大鼠接受假手术。所有动物通过胃内插管进行为期4天的乙醇中毒期。对中毒和戒断评估进行盲法操作。6-羟基多巴胺损伤似乎并未影响对乙醇的耐受性。然而，在戒断期间，损伤动物在某些非惊厥性戒断体征的评分上出现了轻微但具有统计学意义的变化，但两组之间自发性和听源性惊厥发作的发生率和强度并无差异。