Clemmesen L, Hemmingsen R
Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):345-50. doi: 10.1111/j.1600-0773.1984.tb01993.x.
An animal model of repeated alcohol intoxication-withdrawal episodes consisting in a 2-day period of intoxication followed by 5 days abstinence in a 17 week period of study is presented. Gastric intubation was used. As a group the animals presented a statistically significant increase of convulsive withdrawal phenomena which during the 10th and 17th episode was comparable to the withdrawal reaction in abstinent 4-day alcohol-intoxicated animals. It is suggested that the present model may represent a paradigm for the study of effects of multiple ethanol withdrawal episodes.
本文介绍了一种重复酒精中毒-戒断发作的动物模型，该模型在为期17周的研究中，先有2天的中毒期，随后是5天的戒断期。采用胃插管法。作为一个群体，动物出现了惊厥性戒断现象的统计学显著增加，在第10次和第17次发作期间，这种现象与戒酒4天的酒精中毒动物的戒断反应相当。有人认为，目前的模型可能代表了一种研究多次乙醇戒断发作影响的范例。
