Das Milirani, Kumar Rahul, Kumar Vikash, Gurusubramanian Guruswami, Roy Vikas Kumar
Department of Zoology, Mizoram University, Aizawl, Mizoram, 796 004, India.
Department of Biotechnology, Mahatma Gandhi Central University, Motihari, Bihar, 845401, India.
J Mol Histol. 2025 Jun 17;56(4):197. doi: 10.1007/s10735-025-10492-6.
The male and female mouse skin differs in their structure. Leptin, adiponectin, resistin and omentin are adipokines, which expresses in the skin. Apelin is an adipokines, which binds to a its receptor (APJ) and elicits various biological functions in the different tissues. However, the expression of apelin and APJ has not been shown in the mice skin. Since the male female differs, thus, it is hypothesized that apelin and APJ expression might also show gender-wise differences. Our results showed that apelin and APJ are expressed in the epidermal layer, hair follicle and sebaceous glands of male and female skin. This result suggests that apelin-mediated signalling could be different in the male and female skin. Hair follicle and sebaceous gland in the female skin also showed an increased abundance of apelin, which further suggests the role of apelin, in hair growth and sebaceous gland functions. Apelin-mediated signaling in the skin might be gender-dependent. Elevated expression of ERs in female skin coincides with increased apelin and APJ and decreased apelin and APJ expression in male skin coincides with the decreased androgen receptor. Thus, it may be suggested that sex hormonal signaling could be reason for gender wise difference in apelin and APJ expression in skin. Furthermore, apelin signaling would be important for both male and female skin physiological processes, however, apelin signaling could be pronounced in the female skin compared to the male skin. The exact role of gender base apelin signaling needs further investigation in relation proliferation.
雄性和雌性小鼠的皮肤结构存在差异。瘦素、脂联素、抵抗素和网膜素是在皮肤中表达的脂肪因子。阿片肽是一种脂肪因子，它与其受体（APJ）结合并在不同组织中引发各种生物学功能。然而，阿片肽和APJ在小鼠皮肤中的表达尚未见报道。由于雄性和雌性存在差异，因此，推测阿片肽和APJ的表达可能也存在性别差异。我们的结果表明，阿片肽和APJ在雄性和雌性皮肤的表皮层、毛囊和皮脂腺中均有表达。这一结果表明，阿片肽介导的信号在雄性和雌性皮肤中可能不同。雌性皮肤中的毛囊和皮脂腺中阿片肽的丰度也增加，这进一步表明阿片肽在头发生长和皮脂腺功能中的作用。皮肤中阿片肽介导的信号可能具有性别依赖性。雌性皮肤中雌激素受体的表达升高与阿片肽和APJ的增加相一致，而雄性皮肤中阿片肽和APJ的表达降低与雄激素受体的减少相一致。因此，可能提示性激素信号可能是皮肤中阿片肽和APJ表达性别差异的原因。此外，阿片肽信号对雄性和雌性皮肤的生理过程都很重要，然而，与雄性皮肤相比，阿片肽信号在雌性皮肤中可能更明显。基于性别的阿片肽信号的确切作用在增殖方面还需要进一步研究。
