Reese B E
Brain Res. 1985 Oct;354(2):288-92. doi: 10.1016/0165-3806(85)90181-6.
The topography of aberrant ipsilateral retinogeniculate projections following ablation of the superior colliculus in infancy has been examined. Rat pups received a unilateral ablation of the superior colliculus in infancy, which is known to produce an aberrant ipsilateral retinogeniculate projection in the caudal quarter of this nucleus, ipsilateral to the ablation. When adult, each rat received a retinal lesion in the eye ipsilateral to the ablation at varying locations along the temporal crescent and the brains were subsequently processed for anterograde degeneration. The topographic relationship between the retina's temporal crescent and the ipsilateral dorsal lateral geniculate nucleus appeared normal in the rostral three quarters of the nucleus, but an aberrant projection from the far temporal retina (the upper temporal crescent) was demonstrated in the caudal quarter of the nucleus, residing dorsolaterally beneath the optic tract. This location within the dorsal lateral geniculate nucleus normally receives its retinal input from the contralateral temporal retina at reduced eccentricity. As these two retinal regions are likely to be binocularly conjugate, it is proposed that these rearrangements in retinal terminal fields following early collicular ablation produce an ocularly aberrant yet visuotopically appropriate retinogeniculate projection.
对婴儿期上丘切除术后同侧视网膜膝状体异常投射的拓扑结构进行了研究。幼鼠在婴儿期接受了单侧上丘切除，已知这会在该核的尾侧四分之一区域产生异常的同侧视网膜膝状体投射，该区域与切除侧同侧。成年后，每只大鼠在与切除侧同侧的眼睛沿着颞侧新月的不同位置接受视网膜损伤，随后对大脑进行顺行性变性处理。在该核的前三分之四区域，视网膜颞侧新月与同侧背外侧膝状体核之间的拓扑关系似乎正常，但在该核的尾侧四分之一区域显示出来自远颞侧视网膜（颞侧新月上部）的异常投射，位于视束下方的背外侧。背外侧膝状体核内的这个位置通常从对侧颞侧视网膜以较小的离心率接收其视网膜输入。由于这两个视网膜区域可能是双眼共轭的，因此有人提出，早期上丘切除术后视网膜终末场的这些重排会产生一种眼性异常但视觉拓扑上合适的视网膜膝状体投射。
