He Xu, Chen Mimi, Zhang Xiongjinfu, Cheng Xinyi, Chen Yida, Shen Hao, Yang Huilin, Shi Qin, Niu Junjie
Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Medical College of Soochow University, 899 Pinghai Road, Suzhou, Jiangsu 215031, China.
Department of Orthopedics, Children Hospital of Soochow University, No.92 Zhongnan Street, Suzhou, Jiangsu 215000, China.
Fundam Res. 2024 Feb 12;5(3):1063-1072. doi: 10.1016/j.fmre.2024.02.002. eCollection 2025 May.
Osteoporosis (OP) is a systemic skeletal disease characterized by reduced bone mass and a degenerative bone microarchitecture. Apigenin (API), a flavonoid derived mainly from celery, has been reported to be beneficial for the treatment of OP; however, the underlying mechanisms remain unclear. Moreover, the effects of API on bone-forming cells, including mesenchymal stem cells and osteoblasts, remain unclear. In the present study, we first determined that API treatment could promote bone formation, improve bone metabolism in ovariectomized (OVX) mice, and effectively ameliorate bone loss, as supported by micro-CT scanning and histological staining of mouse femurs. investigations have confirmed that API has a bidirectional regulatory effect on bone metabolism, promoteing osteogenic differentiation and inhibiting osteoclastogenesis. The further study displayed that the promotion of osteogenesis of bone marrow-derived mesenchymal stem cells from OVX mice mainly through regulating SIRT1 and its downstream HIF1α signaling. In summary, API treatment may be a novel and promising therapeutic strategy for the treatment of OP.
骨质疏松症（OP）是一种全身性骨骼疾病，其特征是骨量减少和骨微结构退化。芹菜素（API）是一种主要来源于芹菜的黄酮类化合物，据报道对OP的治疗有益；然而，其潜在机制仍不清楚。此外，API对包括间充质干细胞和成骨细胞在内的骨形成细胞的影响也不清楚。在本研究中，我们首先确定，通过小鼠股骨的显微CT扫描和组织学染色证实，API治疗可促进去卵巢（OVX）小鼠的骨形成，改善骨代谢，并有效改善骨质流失。研究证实，API对骨代谢具有双向调节作用，可促进成骨分化并抑制破骨细胞生成。进一步研究表明，API促进OVX小鼠骨髓间充质干细胞成骨主要是通过调节SIRT1及其下游的HIF1α信号通路。总之，API治疗可能是一种治疗OP的新型且有前景的治疗策略。
