基于免疫检查点抑制剂联合治疗时代的转移性肾细胞癌疾病反应 - Suppr

Metastatic renal cell carcinoma disease response in the era of immune checkpoint inhibitor-based combinations.

作者信息

Ostrowski Micah, Gebrael Georges, Maughan Benjamin L

机构信息

Division of Medical Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

出版信息

Transl Androl Urol. 2025 May 30;14(5):1169-1173. doi: 10.21037/tau-2025-93. Epub 2025 May 27.

DOI:10.21037/tau-2025-93

PMID:40529030

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12170065/

Abstract

摘要

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Metastatic renal cell carcinoma disease response in the era of immune checkpoint inhibitor-based combinations.基于免疫检查点抑制剂联合治疗时代的转移性肾细胞癌疾病反应

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Changes in Real-World Outcomes in Patients with Metastatic Renal Cell Carcinoma from the Molecular-Targeted Therapy Era to the Immune Checkpoint Inhibitor Era.从分子靶向治疗时代到免疫检查点抑制剂时代转移性肾细胞癌患者真实世界结局的变化。

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Determinants of treatment for first-line immune-based combinations in metastatic renal cell carcinoma: a critical overview of recent evidence.一线免疫治疗方案治疗转移性肾细胞癌的决定因素：近期证据的批判性综述。

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Therapeutic sequencing in the era of first-line immune checkpoint inhibitor combinations, a novel challenge in patients with metastatic clear-cell renal cell carcinoma.一线免疫检查点抑制剂联合治疗时代的治疗序贯策略，转移性透明细胞肾细胞癌患者面临的新挑战。

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Nivolumab plus ipilimumab versus sunitinib for first-line treatment of advanced renal cell carcinoma: extended 8-year follow-up results of efficacy and safety from the phase III CheckMate 214 trial.纳武利尤单抗联合伊匹木单抗对比舒尼替尼用于晚期肾细胞癌的一线治疗：III 期 CheckMate 214 试验疗效和安全性的 8 年扩展随访结果。

Ann Oncol. 2024 Nov;35(11):1026-1038. doi: 10.1016/j.annonc.2024.07.727. Epub 2024 Aug 2.

Characterization of Responses to Lenvatinib plus Pembrolizumab in Patients with Advanced Renal Cell Carcinoma at the Final Prespecified Survival Analysis of the Phase 3 CLEAR Study.CLEAR 研究最终预设生存分析中晚期肾细胞癌患者接受仑伐替尼联合帕博利珠单抗治疗的反应特征。

Eur Urol. 2024 Jul;86(1):4-9. doi: 10.1016/j.eururo.2024.03.015. Epub 2024 Apr 6.

Immune checkpoint inhibitors: Assessment of the performance and the agreement of iRECIST, irRC, and irRECIST.免疫检查点抑制剂：iRECIST、irRC 和 irRECIST 的性能评估和一致性。

J Cancer Res Ther. 2024 Jan 1;20(1):156-162. doi: 10.4103/jcrt.jcrt_1898_22. Epub 2023 Apr 7.

Cytoreductive nephrectomy in the era of immune checkpoint inhibitors: a US Food and Drug Administration pooled analysis.免疫检查点抑制剂时代的细胞减灭性肾切除术：美国食品和药物管理局的汇总分析。

J Natl Cancer Inst. 2024 Jul 1;116(7):1043-1050. doi: 10.1093/jnci/djae066.

Lenvatinib Plus Pembrolizumab Versus Sunitinib in First-Line Treatment of Advanced Renal Cell Carcinoma: Final Prespecified Overall Survival Analysis of CLEAR, a Phase III Study.仑伐替尼联合帕博利珠单抗对比舒尼替尼用于晚期肾细胞癌一线治疗：CLEAR 研究的最终预设总生存分析，一项 III 期研究。

J Clin Oncol. 2024 Apr 10;42(11):1222-1228. doi: 10.1200/JCO.23.01569. Epub 2024 Jan 16.

Impact of Prior Cytoreductive Nephrectomy on Efficacy in Patients with Synchronous Metastatic Renal Cell Carcinoma Treated with Avelumab plus Axitinib or Sunitinib: Post Hoc Analysis from the JAVELIN Renal 101 Phase 3 Trial.先前细胞减灭性肾切除术对阿维鲁单抗联合阿昔替尼或舒尼替尼治疗同步转移性肾细胞癌患者疗效的影响：来自 JAVELIN Renal 101 期 3 试验的事后分析。

Eur Urol. 2024 Jan;85(1):8-12. doi: 10.1016/j.eururo.2023.09.016. Epub 2023 Oct 16.

Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma.舒尼替尼对比干扰素-α治疗转移性肾细胞癌患者的总生存期和更新结果。

J Clin Oncol. 2023 Apr 10;41(11):1965-1971. doi: 10.1200/JCO.22.02623.

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Nivolumab plus cabozantinib versus sunitinib in first-line treatment for advanced renal cell carcinoma (CheckMate 9ER): long-term follow-up results from an open-label, randomised, phase 3 trial.纳武利尤单抗联合卡博替尼与舒尼替尼用于晚期肾细胞癌一线治疗（CheckMate 9ER）：一项开放标签、随机、III 期临床试验的长期随访结果。

Lancet Oncol. 2022 Jul;23(7):888-898. doi: 10.1016/S1470-2045(22)00290-X. Epub 2022 Jun 7.

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Metastatic renal cell carcinoma disease response in the era of immune checkpoint inhibitor-based combinations.

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